Sandbox 50: Difference between revisions
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==Description== | ==Description== | ||
Adenylate Kinase, also known as ADK, is an enzyme that catalyzes the reversible transfer of phosphate between ATP and AMP. It plays an important role in cell maintenance and cell growth being involved with energy metabolism, signaling, and nucleotide synthesis. The enzyme is found in many different organisms, | Adenylate Kinase, also known as ADK, is an phosphotransfer enzyme that catalyzes the reversible transfer of phosphate between ATP and AMP. It plays an important role in cell maintenance and cell growth being involved with energy metabolism, signaling, and nucleotide synthesis. The reaction, ATP + AMP = 2ADP, The enzyme is found in many different organisms, but the following images shows the structure of Adenylate kinase from Yersinia pestis, also known as yeast. | ||
==Structure== | ==Structure== | ||
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==Residues== | ==Residues== | ||
The | The <scene name='Sandbox_50/Ak_hydrophobic_residues/1'>hydrophobic_residues</scene> of ADK, seen in gray, is buried in the interior of the protein. While the <scene name='Sandbox_50/Ak_hydrophilic_residues1/1'>hydrophilic_residues</scene>, all the charged and polar side chains (purple), are on the surface of the protein and exposed. | ||
==Solvent== | |||
<scene name='Sandbox_50/Ak_water5/1'>water5</scene> | |||
==Active Site== | |||
The active site is where the ligand/substrate binds to the enzyme to be catalyzed. In ADK, the <scene name='Sandbox_50/Ak_ligand3/1'>ligand3</scene>, in | |||
<scene name='Sandbox_50/Ak_catalytic_residues/1'>catalytic_residues</scene> | |||
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<scene name='Sandbox_50/Ak_ligand1/1'>ligand</scene> | <scene name='Sandbox_50/Ak_ligand1/1'>ligand</scene> | ||
<scene name='Sandbox_50/Ak_ligand2/1'>ligand2</scene> | <scene name='Sandbox_50/Ak_ligand2/1'>ligand2</scene> | ||
<scene name='Sandbox_50/Ak_solvent1/1'>solvent1</scene> | <scene name='Sandbox_50/Ak_solvent1/1'>solvent1</scene> | ||
<scene name='Sandbox_50/Ak_solvent2/1'>solvent2</scene> | <scene name='Sandbox_50/Ak_solvent2/1'>solvent2</scene> | ||
<scene name='Sandbox_50/Ak_water3/1'>water3</scene> | <scene name='Sandbox_50/Ak_water3/1'>water3</scene> | ||
<scene name='Sandbox_50/Ak_water4/1'>water4</scene> | <scene name='Sandbox_50/Ak_water4/1'>water4</scene> | ||
<scene name='Sandbox_50/Ak_ligand1/1'>ligand1</scene> | <scene name='Sandbox_50/Ak_ligand1/1'>ligand1</scene> | ||