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Growth factor receptor-bound protein: Difference between revisions

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== Your Heading Here (maybe something like 'Structure') ==
== Your Heading Here (maybe something like 'Structure') ==
<StructureSection load='1dq8' size='350' side='right' caption='Structure of HMG-CoA reductase (PDB entry [[1dq8]])' scene=''>
<StructureSection load='1x0n' size='400' side='right' caption='Structure of human Grb2 SH2 domain complex with inhibitor (PDB entry [[1x0n]])' scene=''>
Anything in this section will appear adjacent to the 3D structure and will be scrollable.
 
</StructureSection>
'''Growth factor receptor-bound protein 2''' (GRB2) is an adaptor protein.  It links the epidermal growth factor receptor tyrosine kinase to the activation of Ras and its downstream kinases.  GRB2 contains an SH2 domain which binds tyrosine phosphorylated sequences and 2 SH3 domains which direct complex formation of proline-rich sequences.  GRB2 is involved in signal transduction.
'''Growth factor receptor-bound protein 2''' (GRB2) is an adaptor protein.  It links the epidermal growth factor receptor tyrosine kinase to the activation of Ras and its downstream kinases.  GRB2 contains an SH2 domain which binds tyrosine phosphorylated sequences and 2 SH3 domains which direct complex formation of proline-rich sequences.  GRB2 is involved in signal transduction.


Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman
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