1oc4: Difference between revisions
New page: left|200px<br /> <applet load="1oc4" size="450" color="white" frame="true" align="right" spinBox="true" caption="1oc4, resolution 2.30Å" /> '''LACTATE DEHYDROGENA... |
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==About this Structure== | ==About this Structure== | ||
1OC4 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Plasmodium_berghei Plasmodium berghei]] with NAD, OXM and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OC4 OCA]]. | 1OC4 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Plasmodium_berghei Plasmodium berghei]] with NAD, OXM and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OC4 OCA]]. | ||
==Reference== | ==Reference== | ||
Crystal structure of Plasmodium berghei lactate dehydrogenase indicates the unique structural differences of these enzymes are shared across the Plasmodium genus., Winter VJ, Cameron A, Tranter R, Sessions RB, Brady RL, Mol Biochem Parasitol. 2003 Sep;131(1):1-10. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12967707 12967707] | Crystal structure of Plasmodium berghei lactate dehydrogenase indicates the unique structural differences of these enzymes are shared across the Plasmodium genus., Winter VJ, Cameron A, Tranter R, Sessions RB, Brady RL, Mol Biochem Parasitol. 2003 Sep;131(1):1-10. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12967707 12967707] | ||
[[Category: L-lactate dehydrogenase]] | |||
[[Category: Plasmodium berghei]] | [[Category: Plasmodium berghei]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: oxidoreductase]] | [[Category: oxidoreductase]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:32:47 2007'' | ||
Revision as of 15:28, 30 October 2007
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LACTATE DEHYDROGENASE FROM PLASMODIUM BERGHEI
OverviewOverview
As Plasmodium rely extensively on homolactic fermentation for energy, production, Plasmodium falciparum lactate dehydrogenase (PfLDH)--the key, enzyme in this process--has previously been suggested as a novel target, for antimalarials. This enzyme has distinctive kinetic and structural, properties that distinguish it from its human homologues. In this study, we now describe the expression, kinetic characterisation and crystal, structure determination of the LDH from Plasmodium berghei. This enzyme is, seen to have a similar kinetic profile to its P. falciparum counterpart, exhibiting the characteristic lack of substrate inhibition that, distinguishes plasmodial from human LDHs. The crystal structure of P., berghei lactate dehydrogenase (PbLDH) shows a very similar active site, arrangement ... [(full description)]
About this StructureAbout this Structure
1OC4 is a [Single protein] structure of sequence from [Plasmodium berghei] with NAD, OXM and GOL as [ligands]. Active as [L-lactate dehydrogenase], with EC number [1.1.1.27]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
Crystal structure of Plasmodium berghei lactate dehydrogenase indicates the unique structural differences of these enzymes are shared across the Plasmodium genus., Winter VJ, Cameron A, Tranter R, Sessions RB, Brady RL, Mol Biochem Parasitol. 2003 Sep;131(1):1-10. PMID:12967707
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