Group:MUZIC:DARP: Difference between revisions

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== Structure ==

DARP contains putative nuclear localization signals,four tandem ankyrin-like repeats, potential coiled-coil dimerization motif within its unique aminoterminal domain that mediates the formation of homodimers. <ref name='three'>PMID 16450059</ref>The amino acid sequence of DARP showed high similarity to cardiac ankyrin-repeat protein (CARP) and ankyrin-repeat domain 2 (Ankrd2) with 45 and 36% identities, respectively.Silico analysis of promoter of DARP gene indicated the existence of binding site for PPARγ consensus sequence recognised by PPARγ is positioned upstream of transcriptional start site in the DARP gene(from -18495 to -18517 bp.<ref name='three'>PMID 915920</ref>

DARP contains putative nuclear localization signals,four tandem ankyrin-like repeats, potential coiled-coil dimerization motif within its unique aminoterminal domain that mediates the formation of homodimers. <ref name='three'>PMID 16450059</ref>The amino acid sequence of DARP showed high similarity to cardiac ankyrin-repeat protein (CARP) and ankyrin-repeat domain 2 (Ankrd2) with 45 and 36% identities, respectively.Silico analysis of promoter of DARP gene indicated the existence of binding site for PPARγ consensus sequence recognised by PPARγ is positioned upstream of transcriptional start site in the DARP gene(from -18495 to -18517 bp).<ref name='three'>PMID 915920</ref>

[[Image:DARP.png|center|800px|thumb|Domain architecture and modification sites of '''DARP''']]

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 == Structure ==
-DARP contains putative nuclear localization signals,four tandem ankyrin-like repeats, potential coiled-coil dimerization motif within its unique aminoterminal domain that mediates the formation of homodimers. <ref name='three'>PMID 16450059</ref>The amino acid sequence of DARP showed high similarity to cardiac ankyrin-repeat protein (CARP) and ankyrin-repeat domain 2 (Ankrd2) with 45 and 36% identities, respectively.Silico analysis of promoter of DARP gene indicated the existence of binding site for PPARγ consensus sequence recognised by PPARγ is positioned upstream of transcriptional start site in the DARP gene(from -18495 to -18517 bp.<ref name='three'>PMID 915920</ref>
+DARP contains putative nuclear localization signals,four tandem ankyrin-like repeats, potential coiled-coil dimerization motif within its unique aminoterminal domain that mediates the formation of homodimers. <ref name='three'>PMID 16450059</ref>The amino acid sequence of DARP showed high similarity to cardiac ankyrin-repeat protein (CARP) and ankyrin-repeat domain 2 (Ankrd2) with 45 and 36% identities, respectively.Silico analysis of promoter of DARP gene indicated the existence of binding site for PPARγ consensus sequence recognised by PPARγ is positioned upstream of transcriptional start site in the DARP gene(from -18495 to -18517 bp).<ref name='three'>PMID 915920</ref>
 [[Image:DARP.png|center|800px|thumb|Domain architecture and modification sites of '''DARP''']]