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New page: left|200px<br /> <applet load="1k83" size="450" color="white" frame="true" align="right" spinBox="true" caption="1k83, resolution 2.80Å" /> '''Crystal Structure o... |
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[[Image:1k83.gif|left|200px]]<br /> | [[Image:1k83.gif|left|200px]]<br /><applet load="1k83" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="1k83" size=" | |||
caption="1k83, resolution 2.80Å" /> | caption="1k83, resolution 2.80Å" /> | ||
'''Crystal Structure of Yeast RNA Polymerase II Complexed with the Inhibitor Alpha Amanitin'''<br /> | '''Crystal Structure of Yeast RNA Polymerase II Complexed with the Inhibitor Alpha Amanitin'''<br /> | ||
==Overview== | ==Overview== | ||
The structure of RNA polymerase II in a complex with the inhibitor | The structure of RNA polymerase II in a complex with the inhibitor alpha-amanitin has been determined by x-ray crystallography. The structure of the complex indicates the likely basis of inhibition and gives unexpected insight into the transcription mechanism. | ||
==About this Structure== | ==About this Structure== | ||
1K83 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Amanita_phalloides Amanita phalloides] and [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] with ZN and MN as [http://en.wikipedia.org/wiki/ligands ligands]. The following page contains interesting information on the relation of 1K83 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb40_1.html RNA Polymerase]]. Active as [http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] Full crystallographic information is available from [http:// | 1K83 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Amanita_phalloides Amanita phalloides] and [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=MN:'>MN</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. The following page contains interesting information on the relation of 1K83 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb40_1.html RNA Polymerase]]. Active as [http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K83 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: RNA Polymerase]] | [[Category: RNA Polymerase]] | ||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: Bushnell, D | [[Category: Bushnell, D A.]] | ||
[[Category: Cramer, P.]] | [[Category: Cramer, P.]] | ||
[[Category: Kornberg, R | [[Category: Kornberg, R D.]] | ||
[[Category: MN]] | [[Category: MN]] | ||
[[Category: ZN]] | [[Category: ZN]] | ||
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[[Category: zinc motifs]] | [[Category: zinc motifs]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:31:11 2008'' | ||
Revision as of 14:31, 21 February 2008
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Crystal Structure of Yeast RNA Polymerase II Complexed with the Inhibitor Alpha Amanitin
OverviewOverview
The structure of RNA polymerase II in a complex with the inhibitor alpha-amanitin has been determined by x-ray crystallography. The structure of the complex indicates the likely basis of inhibition and gives unexpected insight into the transcription mechanism.
About this StructureAbout this Structure
1K83 is a Protein complex structure of sequences from Amanita phalloides and Saccharomyces cerevisiae with and as ligands. The following page contains interesting information on the relation of 1K83 with [RNA Polymerase]. Active as DNA-directed RNA polymerase, with EC number 2.7.7.6 Full crystallographic information is available from OCA.
ReferenceReference
Structural basis of transcription: alpha-amanitin-RNA polymerase II cocrystal at 2.8 A resolution., Bushnell DA, Cramer P, Kornberg RD, Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1218-22. Epub 2002 Jan 22. PMID:11805306
Page seeded by OCA on Thu Feb 21 13:31:11 2008