Group:MUZIC:ANKRD2: Difference between revisions
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Ankrd2 is involved in muscle stress response. It is up-regulated after chronic immobilization in a stretched position.<ref name='one'>PMID 10873377</ref> <ref name='six'>PMID 15677738</ref>, after eccentric contraction <ref name='five'>PMID 14561590</ref> , as well as in injured muscles.<ref name='eleven'>PMID 17926058</ref> Denervation of slow muscle decreases the level of Ankrd2 to below the detection limit in 4 weeks <ref name='six'>PMID 15677738</ref>, whereas denervation of fast muscle increases its expression.<ref name='three'>PMID 12004005</ref> | Ankrd2 is involved in muscle stress response. It is up-regulated after chronic immobilization in a stretched position.<ref name='one'>PMID 10873377</ref> <ref name='six'>PMID 15677738</ref>, after eccentric contraction <ref name='five'>PMID 14561590</ref> , as well as in injured muscles.<ref name='eleven'>PMID 17926058</ref> Denervation of slow muscle decreases the level of Ankrd2 to below the detection limit in 4 weeks <ref name='six'>PMID 15677738</ref>, whereas denervation of fast muscle increases its expression.<ref name='three'>PMID 12004005</ref> | ||
Ankrd2 is not essential for the basal functioning of skeletal muscle, but it is clear its influence on the gene expression program of skeletal muscle cells.<ref name='thirteen'>PMID 17392382</ref> Mainly the Ankrd2 protein has a major role in skeletal muscle formation as a myogenic regulator, since its over-expression in C2C12 myoblasts significantly affects and down-regulates MyoD, myogenin, and their target gene Myh1.<ref name='seven'>PMID 18302940</ref> Altered expression of Ankrd2 has been found in patients suffering from inherited myopathies (muscular dystrophies (MD), congenital myopathies (CM)) and motor neuron diseases (spinal muscular atrophy (SMA), amyotrophic lateral sclerosis (ALS)). | Ankrd2 is not essential for the basal functioning of skeletal muscle, but it is clear its influence on the gene expression program of skeletal muscle cells.<ref name='thirteen'>PMID 17392382</ref> Mainly the Ankrd2 protein has a major role in skeletal muscle formation as a myogenic regulator, since its over-expression in C2C12 myoblasts significantly affects and down-regulates MyoD, myogenin, and their target gene Myh1.<ref name='seven'>PMID 18302940</ref> Altered expression of Ankrd2 has been found in patients suffering from inherited myopathies (muscular dystrophies (MD), congenital myopathies (CM)) and motor neuron diseases (spinal muscular atrophy (SMA), amyotrophic lateral sclerosis (ALS)). | ||
==Localization== | ==Localization== | ||