1k2p: Difference between revisions
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==Overview== | ==Overview== | ||
Bruton's tyrosine kinase is intimately involved in signal transduction | Bruton's tyrosine kinase is intimately involved in signal transduction pathways regulating survival, activation, proliferation, and differentiation of B lineage lymphoid cells. Mutations in the human btk gene are the cause of X-linked agammaglobulinemia, a male immune deficiency disorder characterized by a lack of mature, immunoglobulin-producing B lymphocytes. We have determined the x-ray crystal structure of the Bruton's tyrosine kinase kinase domain in its unphosphorylated state to a 2.1 A resolution. A comparison with the structures of other tyrosine kinases and a possible mechanism of activation unique to Bruton's tyrosine kinase are provided. | ||
==Disease== | ==Disease== | ||
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[[Category: Transferase]] | [[Category: Transferase]] | ||
[[Category: Mao, C.]] | [[Category: Mao, C.]] | ||
[[Category: Uckun, F | [[Category: Uckun, F M.]] | ||
[[Category: Zhou, M.]] | [[Category: Zhou, M.]] | ||
[[Category: bruton tryosine kinase]] | [[Category: bruton tryosine kinase]] | ||
[[Category: kinase domain]] | [[Category: kinase domain]] | ||
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