2bng: Difference between revisions
New page: left|200px<br /> <applet load="2bng" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bng, resolution 2.50Å" /> '''STRUCTURE OF AN M.T... |
No edit summary |
||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
2BNG is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]] with CA as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.2.8 3.3.2.8]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BNG OCA]]. | 2BNG is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]] with CA as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Limonene-1,2-epoxide_hydrolase Limonene-1,2-epoxide hydrolase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.2.8 3.3.2.8]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BNG OCA]]. | ||
==Reference== | ==Reference== | ||
Structure of an atypical epoxide hydrolase from Mycobacterium tuberculosis gives insights into its function., Johansson P, Unge T, Cronin A, Arand M, Bergfors T, Jones TA, Mowbray SL, J Mol Biol. 2005 Sep 2;351(5):1048-56. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16051262 16051262] | Structure of an atypical epoxide hydrolase from Mycobacterium tuberculosis gives insights into its function., Johansson P, Unge T, Cronin A, Arand M, Bergfors T, Jones TA, Mowbray SL, J Mol Biol. 2005 Sep 2;351(5):1048-56. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16051262 16051262] | ||
[[Category: Limonene-1,2-epoxide hydrolase]] | |||
[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| Line 30: | Line 31: | ||
[[Category: structural proteomics in europe]] | [[Category: structural proteomics in europe]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:28:49 2007'' | ||
Revision as of 15:24, 30 October 2007
|
STRUCTURE OF AN M.TUBERCULOSIS LEH-LIKE EPOXIDE HYDROLASE
OverviewOverview
Epoxide hydrolases are vital to many organisms by virtue of their roles in, detoxification, metabolism and processing of signaling molecules. The, Mycobacterium tuberculosis genome encodes an unusually large number of, epoxide hydrolases, suggesting that they might be of particular importance, to these bacteria. We report here the first structure of an epoxide, hydrolase from M.tuberculosis, solved to a resolution of 2.5 A using, single-wavelength anomalous dispersion (SAD) from a, selenomethionine-substituted protein. The enzyme features a deep, active-site pocket created by the packing of three helices onto a curved, six-stranded beta-sheet. This structure is similar to a previously, described limonene-1,2-epoxide hydrolase from Rhodococcus erythropolis and, unlike the ... [(full description)]
About this StructureAbout this Structure
2BNG is a [Single protein] structure of sequence from [Mycobacterium tuberculosis] with CA as [ligand]. Active as [Limonene-1,2-epoxide hydrolase], with EC number [3.3.2.8]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
Structure of an atypical epoxide hydrolase from Mycobacterium tuberculosis gives insights into its function., Johansson P, Unge T, Cronin A, Arand M, Bergfors T, Jones TA, Mowbray SL, J Mol Biol. 2005 Sep 2;351(5):1048-56. PMID:16051262
Page seeded by OCA on Tue Oct 30 14:28:49 2007
Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCA- Pages with broken file links
- Limonene-1,2-epoxide hydrolase
- Mycobacterium tuberculosis
- Single protein
- Arand, M.
- Bergfors, T.
- Johansson, P.
- Jones, T.A.
- Mowbray, S.L.
- SPINE, Structural.Proteomics.in.Europe.
- Unge, T.
- CA
- Epoxide hydrolase
- Hydrolase
- Limonene
- M.tuberculosis
- Spine
- Structural genomics
- Structural proteomics in europe