1jsm: Difference between revisions
New page: left|200px<br /><applet load="1jsm" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jsm, resolution 1.9Å" /> '''STRUCTURE OF H5 AVIAN... |
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[[Image:1jsm.gif|left|200px]]<br /><applet load="1jsm" size=" | [[Image:1jsm.gif|left|200px]]<br /><applet load="1jsm" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1jsm, resolution 1.9Å" /> | caption="1jsm, resolution 1.9Å" /> | ||
'''STRUCTURE OF H5 AVIAN HAEMAGGLUTININ'''<br /> | '''STRUCTURE OF H5 AVIAN HAEMAGGLUTININ'''<br /> | ||
==Overview== | ==Overview== | ||
There are 15 subtypes of influenza A virus (H1-H15), all of which are | There are 15 subtypes of influenza A virus (H1-H15), all of which are found in avian species. Three caused pandemics in the last century: H1 in 1918 (and 1977), H2 in 1957 and H3 in 1968. In 1997, an H5 avian virus and in 1999 an H9 virus caused outbreaks of respiratory disease in Hong Kong. We have determined the three-dimensional structures of the haemagglutinins (HAs) from H5 avian and H9 swine viruses closely related to the viruses isolated from humans in Hong Kong. We have compared them with known structures of the H3 HA from the virus that caused the 1968 H3 pandemic and of the HA--esterase--fusion (HEF) glycoprotein from an influenza C virus. Structure and sequence comparisons suggest that HA subtypes may have originated by diversification of properties that affected the metastability of HAs required for their membrane fusion activities in viral infection. | ||
==About this Structure== | ==About this Structure== | ||
1JSM is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus] with NAG as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | 1JSM is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JSM OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Ha, Y.]] | [[Category: Ha, Y.]] | ||
[[Category: Skehel, J | [[Category: Skehel, J J.]] | ||
[[Category: Stevens, D | [[Category: Stevens, D J.]] | ||
[[Category: Wiley, D | [[Category: Wiley, D C.]] | ||
[[Category: NAG]] | [[Category: NAG]] | ||
[[Category: fusion protein]] | [[Category: fusion protein]] | ||
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[[Category: receptor complex]] | [[Category: receptor complex]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:26:17 2008'' | ||
Revision as of 14:26, 21 February 2008
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STRUCTURE OF H5 AVIAN HAEMAGGLUTININ
OverviewOverview
There are 15 subtypes of influenza A virus (H1-H15), all of which are found in avian species. Three caused pandemics in the last century: H1 in 1918 (and 1977), H2 in 1957 and H3 in 1968. In 1997, an H5 avian virus and in 1999 an H9 virus caused outbreaks of respiratory disease in Hong Kong. We have determined the three-dimensional structures of the haemagglutinins (HAs) from H5 avian and H9 swine viruses closely related to the viruses isolated from humans in Hong Kong. We have compared them with known structures of the H3 HA from the virus that caused the 1968 H3 pandemic and of the HA--esterase--fusion (HEF) glycoprotein from an influenza C virus. Structure and sequence comparisons suggest that HA subtypes may have originated by diversification of properties that affected the metastability of HAs required for their membrane fusion activities in viral infection.
About this StructureAbout this Structure
1JSM is a Protein complex structure of sequences from Influenza a virus with as ligand. Full crystallographic information is available from OCA.
ReferenceReference
H5 avian and H9 swine influenza virus haemagglutinin structures: possible origin of influenza subtypes., Ha Y, Stevens DJ, Skehel JJ, Wiley DC, EMBO J. 2002 Mar 1;21(5):865-75. PMID:11867515
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