1jc7: Difference between revisions
New page: left|200px<br /><applet load="1jc7" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jc7, resolution 2.73Å" /> '''The Laminin-Binding ... |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1jc7.jpg|left|200px]]<br /><applet load="1jc7" size=" | [[Image:1jc7.jpg|left|200px]]<br /><applet load="1jc7" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1jc7, resolution 2.73Å" /> | caption="1jc7, resolution 2.73Å" /> | ||
'''The Laminin-Binding Domain of Agrin is Structurally Related to N-TIMP-1'''<br /> | '''The Laminin-Binding Domain of Agrin is Structurally Related to N-TIMP-1'''<br /> | ||
==Overview== | ==Overview== | ||
Agrin is the key organizer of postsynaptic differentiation at the | Agrin is the key organizer of postsynaptic differentiation at the neuromuscular junction. This organization activity requires the binding of agrin to the synaptic basal lamina. Binding is conferred by the N-terminal agrin (NtA) domain, which mediates a high-affinity interaction with the coiled coil domain of laminins. Here, we report the crystal structure of chicken NtA at 1.6 A resolution. The structure reveals that NtA harbors an oligosaccharide/oligonucleotide-binding fold with several possible sites for the interaction with different ligands. A high structural similarity of NtA with the protease inhibition domain in tissue inhibitor of metalloproteinases-1 (TIMP-1) supports the idea of additional functions of agrin besides synaptogenic activity. | ||
==About this Structure== | ==About this Structure== | ||
1JC7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] with CL as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | 1JC7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] with <scene name='pdbligand=CL:'>CL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JC7 OCA]. | ||
==Reference== | ==Reference== | ||
| Line 21: | Line 21: | ||
[[Category: timp]] | [[Category: timp]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:21:02 2008'' | ||
Revision as of 14:21, 21 February 2008
|
The Laminin-Binding Domain of Agrin is Structurally Related to N-TIMP-1
OverviewOverview
Agrin is the key organizer of postsynaptic differentiation at the neuromuscular junction. This organization activity requires the binding of agrin to the synaptic basal lamina. Binding is conferred by the N-terminal agrin (NtA) domain, which mediates a high-affinity interaction with the coiled coil domain of laminins. Here, we report the crystal structure of chicken NtA at 1.6 A resolution. The structure reveals that NtA harbors an oligosaccharide/oligonucleotide-binding fold with several possible sites for the interaction with different ligands. A high structural similarity of NtA with the protease inhibition domain in tissue inhibitor of metalloproteinases-1 (TIMP-1) supports the idea of additional functions of agrin besides synaptogenic activity.
About this StructureAbout this Structure
1JC7 is a Single protein structure of sequence from Gallus gallus with as ligand. Full crystallographic information is available from OCA.
ReferenceReference
The laminin-binding domain of agrin is structurally related to N-TIMP-1., Stetefeld J, Jenny M, Schulthess T, Landwehr R, Schumacher B, Frank S, Ruegg MA, Engel J, Kammerer RA, Nat Struct Biol. 2001 Aug;8(8):705-9. PMID:11473262
Page seeded by OCA on Thu Feb 21 13:21:02 2008