StudioG24SecL04Tpc5: Difference between revisions
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==Function in Immune System Evasion== | ==Function in Immune System Evasion== | ||
The contributions that VlsE brings to immune evasion of Lyme Disease in B. Burgderfori is brought on by the property of antigenic variation. The variable domain of VlsE keeps the immune system guessing by constantly changing its side chains. The predicted amount of variations due to VlsE sequence is around 10^30 combinations providing ample evasion against immune responses. The variable region also protects the invariable region by covering the latter region, providing antibodies with a small area to attach to the antigen. There is in fact only three antibody chains that can bind to the most consistently active invariable region IR6, Lysine-276, Glutamine-279, Lysine-291, and Lysine-294. The IR6 region exposed is only 13.7% of the entire surface area of VlsE, making immune evasion even easier. | The contributions that VlsE brings to immune evasion of Lyme Disease in B. Burgderfori is brought on by the property of antigenic variation. The variable domain of VlsE keeps the immune system guessing by constantly changing its side chains. The predicted amount of variations due to VlsE sequence is around 10^30 combinations providing ample evasion against immune responses. The variable region also protects the invariable region by covering the latter region, providing antibodies with a small area to attach to the antigen. There is in fact only three antibody chains that can bind to the most consistently active invariable region IR6, Lysine-276, Glutamine-279, Lysine-291, and Lysine-294. The IR6 region exposed is only 13.7% of the entire surface area of VlsE, making immune evasion even easier.<ref name="A">PMID:10569796</ref> | ||
==Clinical Application== | ==Clinical Application== | ||