StudioG24SecL04Tpc5: Difference between revisions
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One of the invariable regions IR6, showed both the highest levels of antigenicity by the Hopps-Woods algorithm and amino acid seqence identify among Borrelia genospecies and strains. Thus it is the most immunodominate region and what allows for the persistent humoral response. Examination of IR6 by the immunoprecipitation with the rabbit anti-C6 antiserum and revealed that IR6 is exposed on VlsE surface. However, IR6 is not accessible to Ab on the outer membrane of the spirochete. | One of the invariable regions IR6, showed both the highest levels of antigenicity by the Hopps-Woods algorithm and amino acid seqence identify among Borrelia genospecies and strains. Thus it is the most immunodominate region and what allows for the persistent humoral response. Examination of IR6 by the immunoprecipitation with the rabbit anti-C6 antiserum and revealed that IR6 is exposed on VlsE surface. However, IR6 is not accessible to Ab on the outer membrane of the spirochete. | ||
<Structure load='1l8w' size='300' frame='true' align='right' caption='IR6:Immunodominate Region of VlsE' scene='StudioG24SecL04Tpc5/Ir6_highlight/ | <Structure load='1l8w' size='300' frame='true' align='right' caption='IR6:Immunodominate Region of VlsE' scene='StudioG24SecL04Tpc5/Ir6_highlight/4' /> | ||
==Function in Immune System Evasion== | ==Function in Immune System Evasion== | ||