G13secL03Tpc3: Difference between revisions
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A more significant <scene name='G13secL03Tpc3/Final_bsheet/3'>structural change</scene> that occurs during the bactericidal Fab complex is the removal of OspB's first four beta sheets. Surrounding sheets shift and overlap to replace the missing sheets. The removal of these sheets can affect the outer surface protein and make the bacteria more susceptible to lysis. | A more significant <scene name='G13secL03Tpc3/Final_bsheet/3'>structural change</scene> that occurs during the bactericidal Fab complex is the removal of OspB's first four beta sheets. Surrounding sheets shift and overlap to replace the missing sheets. The removal of these sheets can affect the outer surface protein and make the bacteria more susceptible to lysis. | ||
=== Destruction=== | === Destruction=== | ||
The bacteria lyses indirectly. The proteolytic activity of the antibody on the bacteria is presumably similar to a membrane attack complex (MAC). The complement system activates the classical pathway, activating effector proteins which insert themselves in the outer membrane of the bacteria and disrupting it and causing death to the cell. <ref name=Article3> PMID:15864264 </ref> | The bacteria lyses indirectly. The proteolytic activity of the antibody on the bacteria is presumably similar to a [http://en.wikipedia.org/wiki/Complement_membrane_attack_complex membrane attack complex] (MAC). The complement system activates the classical pathway, activating effector proteins which insert themselves in the outer membrane of the bacteria and disrupting it and causing death to the cell. <ref name=Article3> PMID:15864264 </ref> | ||
[[Image:Mac attack.PNG|thumb|400px|Mechanism of destruction by MAC on the bacteria, ''Borrelia burgdorferi'']] | [[Image:Mac attack.PNG|thumb|400px|Mechanism of destruction by MAC on the bacteria, ''Borrelia burgdorferi'']] | ||