OspA L03 Group2: Difference between revisions

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Chris DiFiore, Yimei Miao, Kareema Roushdy, Michal Harel

Revision as of 05:40, 16 August 2012 view source Kareema Roushdy (talk \| contribs) 36 edits No edit summary ← Older edit		Revision as of 05:44, 16 August 2012 view source Kareema Roushdy (talk \| contribs) 36 edits No edit summary Newer edit →
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	=='''About OspA'''==		=='''About OspA'''==

	The Borrelia bacteria has proteins on its surface that are different in immunogenic expression (Wagner, 2012). One of these outer surface proteins, OspA, is a [http://en.wikipedia.org/wiki/Lipoprotein lipoprotein] that was found to inhibit bacterial transmission <ref name=Ding >PMID: 11183781</ref>. OspA, known as a potent stimulator of [http://en.wikipedia.org/wiki/Neutrophils nuetrophils], was able to kill the pathogen and attract [http://en.wikipedia.org/wiki/Leukocytes leukocytes]. The interaction of OspA on the antigen and the antibodies was a cascade complement system. Once the complement found OspA on borrelia, it induced an innate response of [http://en.wikipedia.org/wiki/Phagocytosis phagocytosis] allowing the release of ~~proinflammatory~~ cytokines in a host <ref name=Ruprecht >PMID: 18097481</ref> and avoid contracting Lyme disease as it affects the heart, joints, and central nervous ~~system~~ <ref name=Ruprecht >PMID: 18097481</ref>.		The Borrelia bacteria has proteins on its surface that are different in immunogenic expression (Wagner, 2012). One of these outer surface proteins, OspA, is a [http://en.wikipedia.org/wiki/Lipoprotein lipoprotein] that was found to inhibit bacterial transmission <ref name=Ding >PMID: 11183781</ref>. OspA, known as a potent stimulator of [http://en.wikipedia.org/wiki/Neutrophils nuetrophils], was able to kill the pathogen and attract [http://en.wikipedia.org/wiki/Leukocytes leukocytes]. The interaction of OspA on the antigen and the antibodies was a cascade [http://en.wikipedia.org/wiki/Complement_system complement system]. Once the complement found OspA on borrelia, it induced an innate response of [http://en.wikipedia.org/wiki/Phagocytosis phagocytosis] allowing the release of [http://en.wikipedia.org/wiki/Proinflammatory_cytokines proinflamatory cytokines] in a host <ref name=Ruprecht >PMID: 18097481</ref> and avoid contracting Lyme disease as it affects the heart, joints, and [http://en.wikipedia.org/wiki/Central_nervous_system central nervous sytem] <ref name=Ruprecht >PMID: 18097481</ref>.