OspA L03 Group2: Difference between revisions
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=OspA: The Lead to a Cure for Lyme Disease= | |||
=='''Introduction'''== | =='''Introduction'''== | ||
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==Past Experiments on the Effects of OspA== | ==Past Experiments on the Effects of OspA== | ||
Experiments were done using mice to test the effects of OspA on Borrelia bacteria as Lyme diseases progressed in the host. Only when OspA expression was positive the borrelia bacteria in the host admitted to apoptosis. When the outer surface protein was not present the Borrelia bacteria survived and the mice later suffered through skin lesions <ref name=Ding >PMID: 11183781</ref>. On the other hand, if the vaccine with OspA is administered, or the bacteria has moved to a different environment of the cerebrospinal fluid or an inflammatory environment, the bacteria will activate and start to regulate OspA <ref name=Ding >PMID: 11183781</ref> by activating B-cells. Later this induced astrogliosis. | Experiments were done using mice to test the effects of OspA on Borrelia bacteria as Lyme diseases progressed in the host. Only when OspA expression was positive the borrelia bacteria in the host admitted to apoptosis. When the outer surface protein was not present the Borrelia bacteria survived and the mice later suffered through skin lesions <ref name=Ding >PMID: 11183781</ref>. On the other hand, if the vaccine with OspA is administered, or the bacteria has moved to a different environment of the cerebrospinal fluid or an inflammatory environment, the bacteria will activate and start to regulate OspA <ref name=Ding >PMID: 11183781</ref> by activating B-cells. Later this induced astrogliosis. | ||