G15SecL05Tpc3: Difference between revisions
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Lyme disease is a bacterial infectious disease of the skin, joints, nervous system and heart dominantly caused by the spirochete ''Borrelia burgdorferi'', transmitted to humans via the bite of the deer tick ''Ixodes scapularis'' (Becker et al, 2005). The importance of antibodies in controlling such spirochaetal infections was underscored by the discovery of two particular antibodies with distinctive bactericidal properties: the monoclonal antibodies CB2 and H6831 (Connoly et al, 2005). When directed against the C-terminus of the outer-surface protein Osp-B, these fragments are bactericidal even in the absence of complements or phagocytes (Sadziene et al, 1994). | Lyme disease is a bacterial infectious disease of the skin, joints, nervous system and heart dominantly caused by the spirochete ''Borrelia burgdorferi'', transmitted to humans via the bite of the deer tick ''Ixodes scapularis'' (Becker et al, 2005). The importance of antibodies in controlling such spirochaetal infections was underscored by the discovery of two particular antibodies with distinctive bactericidal properties: the monoclonal antibodies CB2 and H6831 (Connoly et al, 2005). When directed against the C-terminus of the outer-surface protein Osp-B, these fragments are bactericidal even in the absence of complements or phagocytes (Sadziene et al, 1994). | ||
== Outer Surface Protein B (Osp-B) of the ''Borrelia burgdorferi'' Spirochete Bacterium | == Outer Surface Protein B (Osp-B) of the ''Borrelia burgdorferi'' Spirochete Bacterium Function == | ||
<Structure load='1rjl' size='300' frame='true' align='right' caption='OspB-CT-H6831 Bound Complex' scene='Insert optional scene name here' /> | <Structure load='1rjl' size='300' frame='true' align='right' caption='OspB-CT-H6831 Bound Complex' scene='Insert optional scene name here' /> | ||
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*[http://en.wikipedia.org/wiki/Monoclonal_antibodies Monoclonal Antibodies] | *[http://en.wikipedia.org/wiki/Monoclonal_antibodies Monoclonal Antibodies] | ||
*[http://www.arthritis.org/ Arthritis] Arthritis Foundation Webpage | *[http://www.arthritis.org/ Arthritis] Arthritis Foundation Webpage | ||
==Notes and Literature References== | ==Notes and Literature References== | ||