1gc1: Difference between revisions
New page: left|200px<br /> <applet load="1gc1" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gc1, resolution 2.5Å" /> '''HIV-1 GP120 CORE COM... |
No edit summary |
||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
1GC1 is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] and [[http://en.wikipedia.org/wiki/ | 1GC1 is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] and [[http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]] with NAG as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: O. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GC1 OCA]]. | ||
==Reference== | ==Reference== | ||
Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody., Kwong PD, Wyatt R, Robinson J, Sweet RW, Sodroski J, Hendrickson WA, Nature. 1998 Jun 18;393(6686):648-59. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9641677 9641677] | Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody., Kwong PD, Wyatt R, Robinson J, Sweet RW, Sodroski J, Hendrickson WA, Nature. 1998 Jun 18;393(6686):648-59. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9641677 9641677] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Human immunodeficiency virus | [[Category: Human immunodeficiency virus 1]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Hendrickson, W.A.]] | [[Category: Hendrickson, W.A.]] | ||
| Line 28: | Line 28: | ||
[[Category: t-cell surface glycoprotein cd4]] | [[Category: t-cell surface glycoprotein cd4]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:22:44 2007'' | ||
Revision as of 15:18, 30 October 2007
|
HIV-1 GP120 CORE COMPLEXED WITH CD4 AND A NEUTRALIZING HUMAN ANTIBODY
OverviewOverview
The entry of human immunodeficiency virus (HIV) into cells requires the, sequential interaction of the viral exterior envelope glycoprotein, gp120, with the CD4 glycoprotein and a chemokine receptor on the cell surface., These interactions initiate a fusion of the viral and cellular membranes., Although gp120 can elicit virus-neutralizing antibodies, HIV eludes the, immune system. We have solved the X-ray crystal structure at 2.5 A, resolution of an HIV-1 gp120 core complexed with a two-domain fragment of, human CD4 and an antigen-binding fragment of a neutralizing antibody that, blocks chemokine-receptor binding. The structure reveals a cavity-laden, CD4-gp120 interface, a conserved binding site for the chemokine receptor, evidence for a conformational change upon CD4 binding, the nature ... [(full description)]
About this StructureAbout this Structure
1GC1 is a [Protein complex] structure of sequences from [Homo sapiens] and [Human immunodeficiency virus 1] with NAG as [ligand]. Structure known Active Site: O. Full crystallographic information is available from [OCA].
ReferenceReference
Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody., Kwong PD, Wyatt R, Robinson J, Sweet RW, Sodroski J, Hendrickson WA, Nature. 1998 Jun 18;393(6686):648-59. PMID:9641677
Page seeded by OCA on Tue Oct 30 14:22:44 2007
Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCA- Pages with broken file links
- Homo sapiens
- Human immunodeficiency virus 1
- Protein complex
- Hendrickson, W.A.
- Kwong, P.D.
- Robinson, J.
- Sodroski, J.
- Sweet, R.W.
- Wyatt, R.
- NAG
- Antigen-binding fragment of human immunoglobulin 17b
- Complex (hiv envelope protein/cd4/fab)
- Glycosylated protein
- Hiv-1 exterior envelope gp120
- T-cell surface glycoprotein cd4