2c82: Difference between revisions
New page: left|200px<br /> <applet load="2c82" size="450" color="white" frame="true" align="right" spinBox="true" caption="2c82, resolution 1.90Å" /> '''X-RAY STRUCTURE OF ... |
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==About this Structure== | ==About this Structure== | ||
2C82 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]] with SO4 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.267 1.1.1.267]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2C82 OCA]]. | 2C82 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]] with SO4 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/1-deoxy-D-xylulose-5-phosphate_reductoisomerase 1-deoxy-D-xylulose-5-phosphate reductoisomerase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.267 1.1.1.267]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2C82 OCA]]. | ||
==Reference== | ==Reference== | ||
The 1.9 A resolution structure of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate reductoisomerase, a potential drug target., Henriksson LM, Bjorkelid C, Mowbray SL, Unge T, Acta Crystallogr D Biol Crystallogr. 2006 Jul;62(Pt 7):807-13. Epub 2006, Jun 20. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16790937 16790937] | The 1.9 A resolution structure of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate reductoisomerase, a potential drug target., Henriksson LM, Bjorkelid C, Mowbray SL, Unge T, Acta Crystallogr D Biol Crystallogr. 2006 Jul;62(Pt 7):807-13. Epub 2006, Jun 20. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16790937 16790937] | ||
[[Category: 1-deoxy-D-xylulose-5-phosphate reductoisomerase]] | |||
[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: rv2870c]] | [[Category: rv2870c]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:21:39 2007'' | ||
Revision as of 15:16, 30 October 2007
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X-RAY STRUCTURE OF 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, DXR, RV2870C, FROM MYCOBACTERIUM TUBERCULOSIS
OverviewOverview
1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzes the, NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose, 5-phosphate to form 2-C-methyl-D-erythritol 4-phosphate, as the second, step of the deoxyxylulose 5-phosphate/methylerythritol 4-phosphate pathway, found in many bacteria and plants. The end product, isopentenyl, diphosphate, is the precursor of various isoprenoids vital to all living, organisms. The pathway is not found in humans; the mevalonate pathway is, instead used for the formation of isopentenyl diphosphate. This, difference, combined with its essentiality, makes the reductoisomerase an, excellent drug target in a number of pathogenic organisms. The structure, of 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Mycobacterium, tuberculosis (Rv2870c) ... [(full description)]
About this StructureAbout this Structure
2C82 is a [Single protein] structure of sequence from [Mycobacterium tuberculosis] with SO4 as [ligand]. Active as [1-deoxy-D-xylulose-5-phosphate reductoisomerase], with EC number [1.1.1.267]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
The 1.9 A resolution structure of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate reductoisomerase, a potential drug target., Henriksson LM, Bjorkelid C, Mowbray SL, Unge T, Acta Crystallogr D Biol Crystallogr. 2006 Jul;62(Pt 7):807-13. Epub 2006, Jun 20. PMID:16790937
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