1h97: Difference between revisions
New page: left|200px<br /> <applet load="1h97" size="450" color="white" frame="true" align="right" spinBox="true" caption="1h97, resolution 1.17Å" /> '''TREMATODE HEMOGLOBI... |
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==About this Structure== | ==About this Structure== | ||
1H97 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Paramphistomum_epiclitum Paramphistomum epiclitum]] with SO4 and HEM as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H97 OCA]]. | 1H97 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Paramphistomum_epiclitum Paramphistomum epiclitum]] with SO4 and HEM as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Sites: HEA and HEB. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H97 OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: non-vertebrate hemoglobin]] | [[Category: non-vertebrate hemoglobin]] | ||
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Revision as of 15:15, 30 October 2007
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TREMATODE HEMOGLOBIN FROM PARAMPHISTOMUM EPICLITUM
OverviewOverview
Monomeric hemoglobin from the trematode Paramphistomum epiclitum displays, very high oxygen affinity (P(50)<0.001 mm Hg) and an unusual heme distal, site containing tyrosyl residues at the B10 and E7 positions. The crystal, structure of aquo-met P. epiclitum hemoglobin, solved at 1.17 A resolution, via multiwavelength anomalous dispersion techniques (R-factor=0.121), shows that the heme distal site pocket residue TyrB10 is engaged in, hydrogen bonding to the iron-bound ligand. By contrast, residue TyrE7 is, unexpectedly locked next to the CD globin region, in a conformation, unsuitable for heme-bound ligand stabilisation. Such structural, organization of the E7 distal residue differs strikingly from that, observed in the nematode Ascaris suum hemoglobin (bearing TyrB10 and GlnE7, ... [(full description)]
About this StructureAbout this Structure
1H97 is a [Single protein] structure of sequence from [Paramphistomum epiclitum] with SO4 and HEM as [ligands]. Structure known Active Sites: HEA and HEB. Full crystallographic information is available from [OCA].
ReferenceReference
Very high resolution structure of a trematode hemoglobin displaying a TyrB10-TyrE7 heme distal residue pair and high oxygen affinity., Pesce A, Dewilde S, Kiger L, Milani M, Ascenzi P, Marden MC, Van Hauwaert ML, Vanfleteren J, Moens L, Bolognesi M, J Mol Biol. 2001 Jun 22;309(5):1153-64. PMID:11399085
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