1ih4: Difference between revisions

Revision as of 14:11, 21 February 2008

Multi-Conformation Crystal Structure of GGm5CGCC

OverviewOverview

The transition between B- and A-DNA was first observed nearly 50 years ago. We have now mapped this transformation through a set of single-crystal structures of the sequence d(GGCGCC)2, with various intermediates being trapped by methylating or brominating the cytosine bases. The resulting pathway progresses through 13 conformational steps, with a composite structure that pairs A-nucleotides with complementary B-nucleotides serving as a distinct transition intermediate. The details of each step in the conversion of B- to A-DNA are thus revealed at the atomic level, placing intermediates for this and other sequences in the context of a common pathway.

About this StructureAbout this Structure

1IH4 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

ReferenceReference

A crystallographic map of the transition from B-DNA to A-DNA., Vargason JM, Henderson K, Ho PS, Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7265-70. Epub 2001 Jun 5. PMID:11390969

Page seeded by OCA on Thu Feb 21 13:11:48 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:1ih4.gif|left|200px]]<br /><applet load="1ih4" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1ih4.gif|left|200px]]<br /><applet load="1ih4" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1ih4, resolution 1.9&Aring;" />
 '''Multi-Conformation Crystal Structure of GGm5CGCC'''<br />
 ==Overview==
-The transition between B- and A-DNA was first observed nearly 50 years, ago. We have now mapped this transformation through a set of, single-crystal structures of the sequence d(GGCGCC)2, with various, intermediates being trapped by methylating or brominating the cytosine, bases. The resulting pathway progresses through 13 conformational steps, with a composite structure that pairs A-nucleotides with complementary, B-nucleotides serving as a distinct transition intermediate. The details, of each step in the conversion of B- to A-DNA are thus revealed at the, atomic level, placing intermediates for this and other sequences in the, context of a common pathway.
+The transition between B- and A-DNA was first observed nearly 50 years ago. We have now mapped this transformation through a set of single-crystal structures of the sequence d(GGCGCC)2, with various intermediates being trapped by methylating or brominating the cytosine bases. The resulting pathway progresses through 13 conformational steps, with a composite structure that pairs A-nucleotides with complementary B-nucleotides serving as a distinct transition intermediate. The details of each step in the conversion of B- to A-DNA are thus revealed at the atomic level, placing intermediates for this and other sequences in the context of a common pathway.
 ==About this Structure==
-IH4 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1IH4 OCA].
+IH4 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IH4 OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Protein complex]]
 [[Category: Henderson, K.]]
-[[Category: Ho, P.S.]]
+[[Category: Ho, P S.]]
-[[Category: Vargason, J.M.]]
+[[Category: Vargason, J M.]]
 [[Category: b to a dna transition]]
 [[Category: dna transition]]
 [[Category: structural transition]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sat Nov 24 22:00:03 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:11:48 2008''