1ih1: Difference between revisions
New page: left|200px<br /><applet load="1ih1" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ih1, resolution 2.0Å" /> '''Crystal Structure of ... |
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[[Image:1ih1.gif|left|200px]]<br /><applet load="1ih1" size=" | [[Image:1ih1.gif|left|200px]]<br /><applet load="1ih1" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1ih1, resolution 2.0Å" /> | caption="1ih1, resolution 2.0Å" /> | ||
'''Crystal Structure of the B-DNA Hexamer GGCGCC with Cobalt Hexamine Resolved to 2.0 Angstroms'''<br /> | '''Crystal Structure of the B-DNA Hexamer GGCGCC with Cobalt Hexamine Resolved to 2.0 Angstroms'''<br /> | ||
==Overview== | ==Overview== | ||
The transition between B- and A-DNA was first observed nearly 50 years | The transition between B- and A-DNA was first observed nearly 50 years ago. We have now mapped this transformation through a set of single-crystal structures of the sequence d(GGCGCC)2, with various intermediates being trapped by methylating or brominating the cytosine bases. The resulting pathway progresses through 13 conformational steps, with a composite structure that pairs A-nucleotides with complementary B-nucleotides serving as a distinct transition intermediate. The details of each step in the conversion of B- to A-DNA are thus revealed at the atomic level, placing intermediates for this and other sequences in the context of a common pathway. | ||
==About this Structure== | ==About this Structure== | ||
1IH1 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with MG and NCO as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | 1IH1 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=NCO:'>NCO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IH1 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Henderson, K.]] | [[Category: Henderson, K.]] | ||
[[Category: Ho, P | [[Category: Ho, P S.]] | ||
[[Category: Vargason, J | [[Category: Vargason, J M.]] | ||
[[Category: MG]] | [[Category: MG]] | ||
[[Category: NCO]] | [[Category: NCO]] | ||
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[[Category: structural transition]] | [[Category: structural transition]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:11:45 2008'' | ||
