1i27: Difference between revisions
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==Overview== | ==Overview== | ||
The x-ray structure of a C-terminal fragment of the RAP74 subunit of human | The x-ray structure of a C-terminal fragment of the RAP74 subunit of human transcription factor (TF) IIF has been determined at 1.02-A resolution. The alpha/beta structure is strikingly similar to the globular domain of linker histone H5 and the DNA-binding domain of hepatocyte nuclear factor 3gamma (HNF-3gamma), making it a winged-helix protein. The surface electrostatic properties of this compact domain differ significantly from those of bona fide winged-helix transcription factors (HNF-3gamma and RFX1) and from the winged-helix domains found within the RAP30 subunit of TFIIF and the beta subunit of TFIIE. RAP74 has been shown to interact with the TFIIF-associated C-terminal domain phosphatase FCP1, and a putative phosphatase binding site has been identified within the RAP74 winged-helix domain. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Angelis, J | [[Category: Angelis, J De.]] | ||
[[Category: Burley, S | [[Category: Burley, S K.]] | ||
[[Category: Kamada, K.]] | [[Category: Kamada, K.]] | ||
[[Category: Roeder, R | [[Category: Roeder, R G.]] | ||
[[Category: ZN]] | [[Category: ZN]] | ||
[[Category: general transcription factor]] | [[Category: general transcription factor]] | ||
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[[Category: winged-helix domain]] | [[Category: winged-helix domain]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:07:10 2008'' | ||