1i0e: Difference between revisions
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==Overview== | ==Overview== | ||
The crystal structure of human muscle creatine kinase has been determined | The crystal structure of human muscle creatine kinase has been determined by the molecular-replacement method and refined at 3.5A resolution. The structures of both the monomer and the dimer closely resemble those of the other known structures in the creatine kinase family. Two types of dimers, one with a non-crystallographic twofold symmetry axis and the other with a crystallographic twofold symmetry axis, were found to exist simultaneously in the crystal. These dimers form an infinite "double-helix"-like structure along an unusual long crystallographic 3(1) axis. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Lin, Z | [[Category: Lin, Z J.]] | ||
[[Category: Shen, Y | [[Category: Shen, Y Q.]] | ||
[[Category: Tang, L.]] | [[Category: Tang, L.]] | ||
[[Category: Zhou, H | [[Category: Zhou, H M.]] | ||
[[Category: dimer]] | [[Category: dimer]] | ||
[[Category: double helix]] | [[Category: double helix]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:06:45 2008'' | ||
Revision as of 14:06, 21 February 2008
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CRYSTAL STRUCTURE OF CREATINE KINASE FROM HUMAN MUSCLE
OverviewOverview
The crystal structure of human muscle creatine kinase has been determined by the molecular-replacement method and refined at 3.5A resolution. The structures of both the monomer and the dimer closely resemble those of the other known structures in the creatine kinase family. Two types of dimers, one with a non-crystallographic twofold symmetry axis and the other with a crystallographic twofold symmetry axis, were found to exist simultaneously in the crystal. These dimers form an infinite "double-helix"-like structure along an unusual long crystallographic 3(1) axis.
About this StructureAbout this Structure
1I0E is a Single protein structure of sequence from Homo sapiens. Active as Creatine kinase, with EC number 2.7.3.2 Full crystallographic information is available from OCA.
ReferenceReference
Structure of human muscle creatine kinase., Shen YQ, Tang L, Zhou HM, Lin ZJ, Acta Crystallogr D Biol Crystallogr. 2001 Aug;57(Pt 8):1196-200. PMID:11517911
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