1s78: Difference between revisions
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[[Image:1s78.png|left|200px]] | [[Image:1s78.png|left|200px]] | ||
{{STRUCTURE_1s78| PDB=1s78 | SCENE= }} | {{STRUCTURE_1s78| PDB=1s78 | SCENE= }} | ||
===Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex=== | ===Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex=== | ||
{{ABSTRACT_PUBMED_15093539}} | {{ABSTRACT_PUBMED_15093539}} | ||
==About this Structure== | ==About this Structure== | ||
[[1s78]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S78 OCA]. | [[1s78]] is a 6 chain structure of [[Monoclonal Antibody]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S78 OCA]. | ||
==See Also== | |||
*[[Monoclonal Antibody|Monoclonal Antibody]] | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:015093539</ref><ref group="xtra">PMID:012610629</ref><ref group="xtra">PMID:012079396</ref><ref group="xtra">PMID:012204533</ref><references group="xtra"/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
Revision as of 18:15, 27 July 2012
Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complexInsights into ErbB signaling from the structure of the ErbB2-pertuzumab complex
Template:ABSTRACT PUBMED 15093539
About this StructureAbout this Structure
1s78 is a 6 chain structure of Monoclonal Antibody with sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.
See AlsoSee Also
ReferenceReference
[xtra 1][xtra 2][xtra 3][xtra 4]
- ↑ Franklin MC, Carey KD, Vajdos FF, Leahy DJ, de Vos AM, Sliwkowski MX. Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex. Cancer Cell. 2004 Apr;5(4):317-28. PMID:15093539
- ↑ Cho HS, Mason K, Ramyar KX, Stanley AM, Gabelli SB, Denney DW Jr, Leahy DJ. Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab. Nature. 2003 Feb 13;421(6924):756-60. PMID:12610629 doi:http://dx.doi.org/10.1038/nature01392
- ↑ Vajdos FF, Adams CW, Breece TN, Presta LG, de Vos AM, Sidhu SS. Comprehensive functional maps of the antigen-binding site of an anti-ErbB2 antibody obtained with shotgun scanning mutagenesis. J Mol Biol. 2002 Jul 5;320(2):415-28. PMID:12079396 doi:http://dx.doi.org/10.1016/S0022-2836(02)00264-4
- ↑ Agus DB, Akita RW, Fox WD, Lewis GD, Higgins B, Pisacane PI, Lofgren JA, Tindell C, Evans DP, Maiese K, Scher HI, Sliwkowski MX. Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth. Cancer Cell. 2002 Aug;2(2):127-37. PMID:12204533