1hcq: Difference between revisions
New page: left|200px<br /> <applet load="1hcq" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hcq, resolution 2.400Å" /> '''THE CRYSTAL STRUCT... |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1hcq.gif|left|200px]]<br /> | [[Image:1hcq.gif|left|200px]]<br /><applet load="1hcq" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="1hcq" size=" | |||
caption="1hcq, resolution 2.400Å" /> | caption="1hcq, resolution 2.400Å" /> | ||
'''THE CRYSTAL STRUCTURE OF THE ESTROGEN RECEPTOR DNA-BINDING DOMAIN BOUND TO DNA: HOW RECEPTORS DISCRIMINATE BETWEEN THEIR RESPONSE ELEMENTS'''<br /> | '''THE CRYSTAL STRUCTURE OF THE ESTROGEN RECEPTOR DNA-BINDING DOMAIN BOUND TO DNA: HOW RECEPTORS DISCRIMINATE BETWEEN THEIR RESPONSE ELEMENTS'''<br /> | ||
==Overview== | ==Overview== | ||
The nuclear hormone receptors are a superfamily of ligand-activated | The nuclear hormone receptors are a superfamily of ligand-activated DNA-binding transcription factors. We have determined the crystal structure (at 2.4 A) of the fully specific complex between the DNA-binding domain from the estrogen receptor and DNA. The protein binds as a symmetrical dimer to its palindromic binding site consisting of two 6 bp consensus half sites with three intervening base pairs. This structure reveals how the protein recognizes its own half site sequence rather than that of the related glucocorticoid receptor, which differs by only two base pairs. Since all nuclear hormone receptors recognize one or the other of these two consensus half site sequences, this recognition mechanism applies generally to the whole receptor family. | ||
==Disease== | ==Disease== | ||
| Line 11: | Line 10: | ||
==About this Structure== | ==About this Structure== | ||
1HCQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. The following page contains interesting information on the relation of 1HCQ with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb45_1.html Estrogen Receptor]]. Full crystallographic information is available from [http:// | 1HCQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. The following page contains interesting information on the relation of 1HCQ with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb45_1.html Estrogen Receptor]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HCQ OCA]. | ||
==Reference== | ==Reference== | ||
| Line 19: | Line 18: | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Chapman, L.]] | [[Category: Chapman, L.]] | ||
[[Category: Finch, J | [[Category: Finch, J T.]] | ||
[[Category: Rhodes, D.]] | [[Category: Rhodes, D.]] | ||
[[Category: Schwabe, J | [[Category: Schwabe, J W.R.]] | ||
[[Category: ZN]] | [[Category: ZN]] | ||
[[Category: complexed with drug]] | [[Category: complexed with drug]] | ||
[[Category: protein-dna complex]] | [[Category: protein-dna complex]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:59:53 2008'' | ||
