2c1c: Difference between revisions
New page: left|200px<br /> <applet load="2c1c" size="450" color="white" frame="true" align="right" spinBox="true" caption="2c1c, resolution 2.30Å" /> '''STRUCTURAL BASIS OF... |
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==About this Structure== | ==About this Structure== | ||
2C1C is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/ | 2C1C is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Helicoverpa_zea Helicoverpa zea]] with ZN and Y1 as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Carboxypeptidase_B Carboxypeptidase B]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.2 3.4.17.2]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2C1C OCA]]. | ||
==Reference== | ==Reference== | ||
Structural basis of the resistance of an insect carboxypeptidase to plant protease inhibitors., Bayes A, Comellas-Bigler M, Rodriguez de la Vega M, Maskos K, Bode W, Aviles FX, Jongsma MA, Beekwilder J, Vendrell J, Proc Natl Acad Sci U S A. 2005 Nov 15;102(46):16602-7. Epub 2005 Oct 31. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16260742 16260742] | Structural basis of the resistance of an insect carboxypeptidase to plant protease inhibitors., Bayes A, Comellas-Bigler M, Rodriguez de la Vega M, Maskos K, Bode W, Aviles FX, Jongsma MA, Beekwilder J, Vendrell J, Proc Natl Acad Sci U S A. 2005 Nov 15;102(46):16602-7. Epub 2005 Oct 31. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16260742 16260742] | ||
[[Category: | [[Category: Carboxypeptidase B]] | ||
[[Category: Helicoverpa zea]] | |||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Aviles, F.X.]] | [[Category: Aviles, F.X.]] | ||
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[[Category: plant inhibitors]] | [[Category: plant inhibitors]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:12:14 2007'' | ||
Revision as of 15:07, 30 October 2007
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STRUCTURAL BASIS OF THE RESISTANCE OF AN INSECT CARBOXYPEPTIDASE TO PLANT PROTEASE INHIBITORS
OverviewOverview
Corn earworm (Helicoverpa zea), also called tomato fruitworm, is a common, pest of many Solanaceous plants. This insect is known to adapt to the, ingestion of plant serine protease inhibitors by using digestive proteases, that are insensitive to inhibition. We have now identified a B-type, carboxypeptidase of H. zea (CPBHz) insensitive to potato carboxypeptidase, inhibitor (PCI) in corn earworm. To elucidate the structural features, leading to the adaptation of the insect enzyme, the crystal structure of, the recombinant CPBHz protein was determined by x-ray diffraction. CPBHz, is a member of the A/B subfamily of metallocarboxypeptidases, which, displays the characteristic metallocarboxypeptidase alpha/beta-hydrolase, fold, and does not differ essentially from the previously described, ... [(full description)]
About this StructureAbout this Structure
2C1C is a [Single protein] structure of sequence from [Helicoverpa zea] with ZN and Y1 as [ligands]. Active as [Carboxypeptidase B], with EC number [3.4.17.2]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
Structural basis of the resistance of an insect carboxypeptidase to plant protease inhibitors., Bayes A, Comellas-Bigler M, Rodriguez de la Vega M, Maskos K, Bode W, Aviles FX, Jongsma MA, Beekwilder J, Vendrell J, Proc Natl Acad Sci U S A. 2005 Nov 15;102(46):16602-7. Epub 2005 Oct 31. PMID:16260742
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