2c10: Difference between revisions
New page: left|200px<br /> <applet load="2c10" size="450" color="white" frame="true" align="right" spinBox="true" caption="2c10, resolution 2.50Å" /> '''THE STRUCTURE OF A ... |
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==About this Structure== | ==About this Structure== | ||
2C10 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with NAG, CA, CU and CL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.6 1.4.3.6]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2C10 OCA]]. | 2C10 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with NAG, CA, CU and CL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Amine_oxidase_(copper-containing) Amine oxidase (copper-containing)]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.6 1.4.3.6]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2C10 OCA]]. | ||
==Reference== | ==Reference== | ||
Structure of human semicarbazide-sensitive amine oxidase/vascular adhesion protein-1., Jakobsson E, Nilsson J, Ogg D, Kleywegt GJ, Acta Crystallogr D Biol Crystallogr. 2005 Nov;61(Pt 11):1550-62. Epub 2005, Oct 19. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16239734 16239734] | Structure of human semicarbazide-sensitive amine oxidase/vascular adhesion protein-1., Jakobsson E, Nilsson J, Ogg D, Kleywegt GJ, Acta Crystallogr D Biol Crystallogr. 2005 Nov;61(Pt 11):1550-62. Epub 2005, Oct 19. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16239734 16239734] | ||
[[Category: Amine oxidase (copper-containing)]] | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: vascular adhesion]] | [[Category: vascular adhesion]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:12:03 2007'' | ||
Revision as of 15:07, 30 October 2007
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THE STRUCTURE OF A TRUNCATED, SOLUBLE VERSION OF SEMICARBAZIDE-SENSITIVE AMINE OXIDASE
OverviewOverview
Semicarbazide-sensitive amine oxidase (SSAO) belongs to a ubiquitous, family of copper-containing amine oxidases (CuAOs). SSAO is also known as, vascular adhesion protein-1 (VAP-1) and has been identified as one of the, adhesion molecules involved in the leukocyte-extravasation process. The, structure of a truncated soluble form of human SSAO has been solved and, refined to 2.5 A. As expected, SSAO is a homodimer with a fold typical of, the CuAO family. The topaquinone (TPQ) cofactor and a copper ion, characteristic of CuAOs are present in the active site, with the TPQ in, the active ;off-copper' conformation. The structure reveals that a leucine, residue (Leu469) located adjacent to the active site could function as a, gate controlling its accessibility. An RGD motif is displayed on the, ... [(full description)]
About this StructureAbout this Structure
2C10 is a [Single protein] structure of sequence from [Homo sapiens] with NAG, CA, CU and CL as [ligands]. Active as [Amine oxidase (copper-containing)], with EC number [1.4.3.6]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
Structure of human semicarbazide-sensitive amine oxidase/vascular adhesion protein-1., Jakobsson E, Nilsson J, Ogg D, Kleywegt GJ, Acta Crystallogr D Biol Crystallogr. 2005 Nov;61(Pt 11):1550-62. Epub 2005, Oct 19. PMID:16239734
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