1afj: Difference between revisions
New page: left|200px<br /> <applet load="1afj" size="450" color="white" frame="true" align="right" spinBox="true" caption="1afj" /> '''STRUCTURE OF THE MERCURY-BOUND FORM OF MERP... |
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==About this Structure== | ==About this Structure== | ||
1AFJ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]] with HG as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AFJ OCA]]. | 1AFJ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]] with HG as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: HMA. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AFJ OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: periplasmic]] | [[Category: periplasmic]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:11:30 2007'' | ||
Revision as of 15:06, 30 October 2007
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STRUCTURE OF THE MERCURY-BOUND FORM OF MERP, THE PERIPLASMIC PROTEIN FROM THE BACTERIAL MERCURY DETOXIFICATION SYSTEM, NMR, 20 STRUCTURES
OverviewOverview
Bacteria carrying plasmids with the mer operon, which encodes the proteins, responsible for the bacterial mercury detoxification system, have the, ability to transport Hg(II) across the cell membrane into the cytoplasm, where it is reduced to Hg(0). This is significant because metallic mercury, is relatively nontoxic and volatile and thus can be passively eliminated., The structures of the reduced and mercury-bound forms of merP, the, periplasmic protein, which binds Hg(II) and transfers it to the membrane, transport protein merT, have been determined in aqueous solution by, multidimensional NMR spectroscopy. The 72-residue merP protein has a, betaalpha betabeta alphabeta fold with the two alpha helices overlaying a, four-strand antiparallel beta sheet. Structural differences between the, ... [(full description)]
About this StructureAbout this Structure
1AFJ is a [Single protein] structure of sequence from [Shigella flexneri] with HG as [ligand]. Structure known Active Site: HMA. Full crystallographic information is available from [OCA].
ReferenceReference
Structures of the reduced and mercury-bound forms of MerP, the periplasmic protein from the bacterial mercury detoxification system., Steele RA, Opella SJ, Biochemistry. 1997 Jun 10;36(23):6885-95. PMID:9188683
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