2ci8: Difference between revisions
New page: left|200px<br /> <applet load="2ci8" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ci8, resolution 1.80Å" /> '''SH2 DOMAIN OF HUMAN... |
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==About this Structure== | ==About this Structure== | ||
2CI8 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with SO4 and 1PE as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CI8 OCA]]. | 2CI8 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with SO4 and 1PE as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CI8 OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: sh3 domain]] | [[Category: sh3 domain]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:11:08 2007'' | ||
Revision as of 15:06, 30 October 2007
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SH2 DOMAIN OF HUMAN NCK1 ADAPTOR PROTEIN- UNCOMPLEXED
OverviewOverview
Nck proteins are essential Src homology (SH) 2 and SH3 domain-bearing, adapters that modulate actin cytoskeleton dynamics by linking proline-rich, effector molecules to tyrosine kinases or phosphorylated signaling, intermediates. Two mammalian pathogens, enteropathogenic Escherichia coli, and vaccinia virus, exploit Nck as part of their infection strategy., Conflicting data indicate potential differences in the recognition, specificities of the SH2 domains of the isoproteins Nck1 (Nckalpha) and, Nck2 (Nckbeta and Grb4). We have characterized the binding specificities, of both SH2 domains and find them to be essentially indistinguishable., Crystal structures of both domains in complex with phosphopeptides derived, from the enteropathogenic E. coli protein Tir concur in identifying highly, ... [(full description)]
About this StructureAbout this Structure
2CI8 is a [Single protein] structure of sequence from [Homo sapiens] with SO4 and 1PE as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
The phosphotyrosine peptide binding specificity of Nck1 and Nck2 Src homology 2 domains., Frese S, Schubert WD, Findeis AC, Marquardt T, Roske YS, Stradal TE, Heinz DW, J Biol Chem. 2006 Jun 30;281(26):18236-45. Epub 2006 Apr 24. PMID:16636066
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