2j7n: Difference between revisions
New page: left|200px<br /> <applet load="2j7n" size="450" color="white" frame="true" align="right" spinBox="true" caption="2j7n, resolution 2.30Å" /> '''STRUCTURE OF THE RN... |
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==About this Structure== | ==About this Structure== | ||
2J7N is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Neurospora_crassa Neurospora crassa]] with MG and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2J7N OCA]]. | 2J7N is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Neurospora_crassa Neurospora crassa]] with MG and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2J7N OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: rnai response]] | [[Category: rnai response]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:10:14 2007'' | ||
Revision as of 15:05, 30 October 2007
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STRUCTURE OF THE RNAI POLYMERASE FROM NEUROSPORA CRASSA
OverviewOverview
RNA silencing refers to a group of RNA-induced gene-silencing mechanisms, that developed early in the eukaryotic lineage, probably for defence, against pathogens and regulation of gene expression. In plants, protozoa, fungi, and nematodes, but apparently not insects and vertebrates, it, involves a cell-encoded RNA-dependent RNA polymerase (cRdRP) that produces, double-stranded RNA triggers from aberrant single-stranded RNA. We report, the 2.3-A resolution crystal structure of QDE-1, a cRdRP from Neurospora, crassa, and find that it forms a relatively compact dimeric molecule, each, subunit of which comprises several domains with, at its core, a catalytic, apparatus and protein fold strikingly similar to the catalytic core of the, DNA-dependent RNA polymerases responsible for ... [(full description)]
About this StructureAbout this Structure
2J7N is a [Single protein] structure of sequence from [Neurospora crassa] with MG and GOL as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
The structure of an RNAi polymerase links RNA silencing and transcription., Salgado PS, Koivunen MR, Makeyev EV, Bamford DH, Stuart DI, Grimes JM, PLoS Biol. 2006 Dec;4(12):e434. PMID:17147473
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