1gg2: Difference between revisions

Revision as of 13:49, 21 February 2008

G PROTEIN HETEROTRIMER MUTANT GI_ALPHA_1(G203A) BETA_1 GAMMA_2 WITH GDP BOUND

OverviewOverview

The crystallographic structure of the G protein heterotrimer Gi alpha 1(GDP)beta 1 gamma 2 (at 2.3 A) reveals two nonoverlapping regions of contact between alpha and beta, an extended interface between beta and nearly all of gamma, and limited interaction of alpha with gamma. The major alpha/beta interface covers switch II of alpha, and GTP-induced rearrangement of switch II causes subunit dissociation during signaling. Alterations in GDP binding in the heterotrimer (compared with alpha-GDP) explain stabilization of the inactive conformation of alpha by beta gamma. Repeated WD motifs in beta form a circularized sevenfold beta propeller. The conserved cores of these motifs are a scaffold for display of their more variable linkers on the exterior face of each propeller blade.

About this StructureAbout this Structure

1GG2 is a Protein complex structure of sequences from Bos taurus and Rattus norvegicus with as ligand. The following page contains interesting information on the relation of 1GG2 with [G Proteins]. Full crystallographic information is available from OCA.

ReferenceReference

The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2., Wall MA, Coleman DE, Lee E, Iniguez-Lluhi JA, Posner BA, Gilman AG, Sprang SR, Cell. 1995 Dec 15;83(6):1047-58. PMID:8521505

Page seeded by OCA on Thu Feb 21 12:49:39 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1gg2.gif|left|200px]]<br />
+[[Image:1gg2.gif|left|200px]]<br /><applet load="1gg2" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1gg2" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1gg2, resolution 2.4&Aring;" />
 '''G PROTEIN HETEROTRIMER MUTANT GI_ALPHA_1(G203A) BETA_1 GAMMA_2 WITH GDP BOUND'''<br />
 ==Overview==
-The crystallographic structure of the G protein heterotrimer Gi alpha, 1(GDP)beta 1 gamma 2 (at 2.3 A) reveals two nonoverlapping regions of, contact between alpha and beta, an extended interface between beta and, nearly all of gamma, and limited interaction of alpha with gamma. The, major alpha/beta interface covers switch II of alpha, and GTP-induced, rearrangement of switch II causes subunit dissociation during signaling., Alterations in GDP binding in the heterotrimer (compared with alpha-GDP), explain stabilization of the inactive conformation of alpha by beta gamma., Repeated WD motifs in beta form a circularized sevenfold beta propeller., The conserved cores of these motifs are a scaffold for display of their, more variable linkers on the exterior face of each propeller blade.
+The crystallographic structure of the G protein heterotrimer Gi alpha 1(GDP)beta 1 gamma 2 (at 2.3 A) reveals two nonoverlapping regions of contact between alpha and beta, an extended interface between beta and nearly all of gamma, and limited interaction of alpha with gamma. The major alpha/beta interface covers switch II of alpha, and GTP-induced rearrangement of switch II causes subunit dissociation during signaling. Alterations in GDP binding in the heterotrimer (compared with alpha-GDP) explain stabilization of the inactive conformation of alpha by beta gamma. Repeated WD motifs in beta form a circularized sevenfold beta propeller. The conserved cores of these motifs are a scaffold for display of their more variable linkers on the exterior face of each propeller blade.
 ==About this Structure==
-GG2 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with GDP as [http://en.wikipedia.org/wiki/ligand ligand]. The following page contains interesting information on the relation of 1GG2 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb58_1.html G Proteins]]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GG2 OCA].
+GG2 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=GDP:'>GDP</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. The following page contains interesting information on the relation of 1GG2 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb58_1.html G Proteins]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GG2 OCA].
 ==Reference==
@@ Line 16: / Line 15: @@
 [[Category: Protein complex]]
 [[Category: Rattus norvegicus]]
-[[Category: Sprang, S.R.]]
+[[Category: Sprang, S R.]]
-[[Category: Wall, M.A.]]
+[[Category: Wall, M A.]]
 [[Category: GDP]]
 [[Category: complex (gtp-binding/transducer)]]
@@ Line 27: / Line 26: @@
 [[Category: wd40]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 18 09:00:49 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:49:39 2008''