1ta2: Difference between revisions

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[[Image:1ta2.png|left|200px]]
[[Image:1ta2.png|left|200px]]


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{{STRUCTURE_1ta2|  PDB=1ta2  |  SCENE=  }}  
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===Crystal structure of thrombin in complex with compound 1===
===Crystal structure of thrombin in complex with compound 1===


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{{ABSTRACT_PUBMED_9703466}}
{{ABSTRACT_PUBMED_9703466}}


==About this Structure==
==About this Structure==
[[1ta2]] is a 2 chain structure of [[Hirudin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TA2 OCA].  
[[1ta2]] is a 2 chain structure of [[Hirudin]] and [[Thrombin]] with sequence from [http://en.wikipedia.org/wiki/Hirudo_medicinalis Hirudo medicinalis] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TA2 OCA].  


==See Also==
==See Also==
*[[Hirudin]]
*[[Hirudin|Hirudin]]
*[[Thrombin|Thrombin]]


==Reference==
==Reference==
<ref group="xtra">PMID:9703466</ref><references group="xtra"/>
<ref group="xtra">PMID:009703466</ref><references group="xtra"/>
[[Category: Hirudo medicinalis]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Thrombin]]
[[Category: Thrombin]]
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[[Category: Yan, Y.]]
[[Category: Yan, Y.]]
[[Category: Blood clotting]]
[[Category: Blood clotting]]
[[Category: Hydrolase/inhibitor complex]]
[[Category: Hydrolase]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Thrombin inhibitor complex]]
[[Category: Thrombin inhibitor complex]]

Revision as of 09:51, 27 July 2012

File:1ta2.png

Template:STRUCTURE 1ta2

Crystal structure of thrombin in complex with compound 1Crystal structure of thrombin in complex with compound 1

Template:ABSTRACT PUBMED 9703466

About this StructureAbout this Structure

1ta2 is a 2 chain structure of Hirudin and Thrombin with sequence from Hirudo medicinalis and Homo sapiens. Full crystallographic information is available from OCA.

See AlsoSee Also

ReferenceReference

[xtra 1]

  1. ↑ Tucker TJ, Brady SF, Lumma WC, Lewis SD, Gardell SJ, Naylor-Olsen AM, Yan Y, Sisko JT, Stauffer KJ, Lucas BJ, Lynch JJ, Cook JJ, Stranieri MT, Holahan MA, Lyle EA, Baskin EP, Chen IW, Dancheck KB, Krueger JA, Cooper CM, Vacca JP. Design and synthesis of a series of potent and orally bioavailable noncovalent thrombin inhibitors that utilize nonbasic groups in the P1 position. J Med Chem. 1998 Aug 13;41(17):3210-9. PMID:9703466 doi:http://dx.doi.org/10.1021/jm9801713

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