3s2v: Difference between revisions

Revision as of 07:45, 27 July 2012

3s2v is a 2 chain structure of Ionotropic Glutamate Receptors with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

↑ Venskutonyte R, Butini S, Sanna Coccone S, Gemma S, Brindisi M, Kumar V, Guarino E, Maramai S, Valenti S, Amir A, Valades EA, Frydenvang K, Kastrup JS, Novellino E, Campiani G, Pickering DS. Selective Kainate Receptor (GluK1) Ligands Structurally Based upon 1H-Cyclopentapyrimidin-2,4(1H,3H)-dione: Synthesis, Molecular Modeling, and Pharmacological and Biostructural Characterization. J Med Chem. 2011 Jun 13. PMID:21619066 doi:10.1021/jm2004078
↑ Naur P, Vestergaard B, Skov LK, Egebjerg J, Gajhede M, Kastrup JS. Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate. FEBS Lett. 2005 Feb 14;579(5):1154-60. PMID:15710405 doi:10.1016/j.febslet.2005.01.012

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 [[Image:3s2v.png|left|200px]]
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 ===Crystal Structure of the Ligand Binding Domain of GluK1 in Complex with an Antagonist (S)-1-(2'-Amino-2'-carboxyethyl)-3-[(2-carboxythien-3-yl)methyl]thieno[3,4-d]pyrimidin-2,4-dione at 2.5 A Resolution===
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