1g37: Difference between revisions
New page: left|200px<br /> <applet load="1g37" size="450" color="white" frame="true" align="right" spinBox="true" caption="1g37, resolution 2.0Å" /> '''CRYSTAL STRUCTURE OF... |
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[[Image:1g37.gif|left|200px]]<br /> | [[Image:1g37.gif|left|200px]]<br /><applet load="1g37" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="1g37" size=" | |||
caption="1g37, resolution 2.0Å" /> | caption="1g37, resolution 2.0Å" /> | ||
'''CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN COMPLEXED WITH BCH-10556 AND EXOSITE-DIRECTED PEPTIDE'''<br /> | '''CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN COMPLEXED WITH BCH-10556 AND EXOSITE-DIRECTED PEPTIDE'''<br /> | ||
==Overview== | ==Overview== | ||
Bicyclic piperazinone based thrombin inhibitors of general structure 2 | Bicyclic piperazinone based thrombin inhibitors of general structure 2 were prepared and evaluated in vitro and in vivo. These inhibitors, having in common an electrophilic basic trans-cyclohexylamine P1 residue, displayed high thrombin affinity, high selectivity against trypsin and good in vivo efficacy in the rat arterial thrombosis model. | ||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
1G37 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with 110 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5] Full crystallographic information is available from [http:// | 1G37 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=110:'>110</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G37 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Thrombin]] | [[Category: Thrombin]] | ||
[[Category: Bachand, B.]] | [[Category: Bachand, B.]] | ||
[[Category: Edmunds, J | [[Category: Edmunds, J J.]] | ||
[[Category: Leblond, L.]] | [[Category: Leblond, L.]] | ||
[[Category: Siddiqui, M | [[Category: Siddiqui, M A.]] | ||
[[Category: St-Denis, Y.]] | [[Category: St-Denis, Y.]] | ||
[[Category: Tarazi, M.]] | [[Category: Tarazi, M.]] | ||
[[Category: Winocour, P | [[Category: Winocour, P D.]] | ||
[[Category: 110]] | [[Category: 110]] | ||
[[Category: inhibitor]] | [[Category: inhibitor]] | ||
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[[Category: thrombin]] | [[Category: thrombin]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:45:32 2008'' | ||
