1fpr: Difference between revisions
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==Overview== | ==Overview== | ||
The substrate specificity of the catalytic domain of SHP-1, an important | The substrate specificity of the catalytic domain of SHP-1, an important regulator in the proliferation and development of hematopoietic cells, is critical for understanding the physiological functions of SHP-1. Here we report the crystal structures of the catalytic domain of SHP-1 complexed with two peptide substrates derived from SIRPalpha, a member of the signal-regulatory proteins. We show that the variable beta5-loop-beta6 motif confers SHP-1 substrate specificity at the P-4 and further N-terminal subpockets. We also observe a novel residue shift at P-2, the highly conserved subpocket in protein- tyrosine phosphatases. Our observations provide new insight into the substrate specificity of SHP-1. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Niu, Z.]] | [[Category: Niu, Z.]] | ||
[[Category: Yang, J.]] | [[Category: Yang, J.]] | ||
[[Category: Zhao, Z | [[Category: Zhao, Z J.]] | ||
[[Category: Zhou, G | [[Category: Zhou, G W.]] | ||
[[Category: protein tyrosine phosphatase]] | [[Category: protein tyrosine phosphatase]] | ||
[[Category: residue shift]] | [[Category: residue shift]] | ||
[[Category: substrate specificity]] | [[Category: substrate specificity]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:41:16 2008'' | ||