1apq: Difference between revisions
New page: left|200px<br /> <applet load="1apq" size="450" color="white" frame="true" align="right" spinBox="true" caption="1apq" /> '''STRUCTURE OF THE EGF-LIKE MODULE OF HUMAN C... |
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==About this Structure== | ==About this Structure== | ||
1APQ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.41 3.4.21.41]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1APQ OCA]]. | 1APQ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]]. Active as [[http://en.wikipedia.org/wiki/Complement_subcomponent_C1r Complement subcomponent C1r]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.41 3.4.21.41]]. Structure known Active Site: CAB. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1APQ OCA]]. | ||
==Reference== | ==Reference== | ||
Solution structure of the epidermal growth factor (EGF)-like module of human complement protease C1r, an atypical member of the EGF family., Bersch B, Hernandez JF, Marion D, Arlaud GJ, Biochemistry. 1998 Feb 3;37(5):1204-14. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9477945 9477945] | Solution structure of the epidermal growth factor (EGF)-like module of human complement protease C1r, an atypical member of the EGF family., Bersch B, Hernandez JF, Marion D, Arlaud GJ, Biochemistry. 1998 Feb 3;37(5):1204-14. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9477945 9477945] | ||
[[Category: Complement subcomponent C1r]] | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: serine protease]] | [[Category: serine protease]] | ||
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Revision as of 14:59, 30 October 2007
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STRUCTURE OF THE EGF-LIKE MODULE OF HUMAN C1R, NMR, 19 STRUCTURES
OverviewOverview
The calcium-dependent interaction between C1r and C1s, the two homologous, serine proteases of the first component of human complement C1, is, mediated by their N-terminal regions. The latter comprise an epidermal, growth factor (EGF)-like module exhibiting the consensus sequence, characteristic of Ca(2+)-binding EGF modules, surrounded by two CUB, modules. Due to its Ca2+ binding ability, the C1r EGF-like module, (C1r-EGF) is supposed to participate in the C1r-C1s interaction. An, additional interesting feature of C1r-EGF is the unusually large loop, connecting the first two conserved cysteine residues. The solution, structure of synthetic C1r-EGF (residues 123-175) has been determined, using nuclear magnetic resonance and combined simulated, annealing-restrained molecular dynamics ... [(full description)]
About this StructureAbout this Structure
1APQ is a [Single protein] structure of sequence from [Homo sapiens]. Active as [Complement subcomponent C1r], with EC number [3.4.21.41]. Structure known Active Site: CAB. Full crystallographic information is available from [OCA].
ReferenceReference
Solution structure of the epidermal growth factor (EGF)-like module of human complement protease C1r, an atypical member of the EGF family., Bersch B, Hernandez JF, Marion D, Arlaud GJ, Biochemistry. 1998 Feb 3;37(5):1204-14. PMID:9477945
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