2j1x: Difference between revisions
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[[Image:2j1x.png|left|200px]] | [[Image:2j1x.png|left|200px]] | ||
{{STRUCTURE_2j1x| PDB=2j1x | SCENE= }} | {{STRUCTURE_2j1x| PDB=2j1x | SCENE= }} | ||
===HUMAN P53 CORE DOMAIN MUTANT M133L-V203A-Y220C-N239Y-N268D=== | ===HUMAN P53 CORE DOMAIN MUTANT M133L-V203A-Y220C-N239Y-N268D=== | ||
{{ABSTRACT_PUBMED_17015838}} | {{ABSTRACT_PUBMED_17015838}} | ||
==About this Structure== | ==About this Structure== | ||
[[2j1x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J1X OCA]. | [[2j1x]] is a 2 chain structure of [[P53]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J1X OCA]. | ||
==See Also== | |||
*[[P53|P53]] | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:017015838</ref><ref group="xtra">PMID:014534297</ref><ref group="xtra">PMID:015703170</ref><references group="xtra"/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Fersht, A R.]] | [[Category: Fersht, A R.]] | ||
[[Category: Joerger, A C.]] | [[Category: Joerger, A C.]] | ||
[[Category: Activator]] | [[Category: Activator]] | ||
[[Category: Anti-oncogene]] | [[Category: Anti-oncogene]] | ||
[[Category: Apoptosis]] | [[Category: Apoptosis]] | ||
| Line 43: | Line 33: | ||
[[Category: P53 dna-binding domain]] | [[Category: P53 dna-binding domain]] | ||
[[Category: Phosphorylation]] | [[Category: Phosphorylation]] | ||
[[Category: Second-site suppressor mutation]] | [[Category: Second-site suppressor mutation]] | ||
[[Category: Superstable mutant]] | [[Category: Superstable mutant]] | ||
| Line 50: | Line 39: | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
[[Category: Tumor suppressor]] | [[Category: Tumor suppressor]] | ||
Revision as of 02:37, 27 July 2012
HUMAN P53 CORE DOMAIN MUTANT M133L-V203A-Y220C-N239Y-N268DHUMAN P53 CORE DOMAIN MUTANT M133L-V203A-Y220C-N239Y-N268D
Template:ABSTRACT PUBMED 17015838
About this StructureAbout this Structure
2j1x is a 2 chain structure of P53 with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See AlsoSee Also
ReferenceReference
- ↑ Joerger AC, Ang HC, Fersht AR. Structural basis for understanding oncogenic p53 mutations and designing rescue drugs. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15056-61. Epub 2006 Oct 2. PMID:17015838
- ↑ Joerger AC, Allen MD, Fersht AR. Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations. J Biol Chem. 2004 Jan 9;279(2):1291-6. Epub 2003 Oct 8. PMID:14534297 doi:10.1074/jbc.M309732200
- ↑ Joerger AC, Ang HC, Veprintsev DB, Blair CM, Fersht AR. Structures of p53 cancer mutants and mechanism of rescue by second-site suppressor mutations. J Biol Chem. 2005 Apr 22;280(16):16030-7. Epub 2005 Feb 9. PMID:15703170 doi:http://dx.doi.org/10.1074/jbc.M500179200
Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCACategories:
- Pages with broken file links
- Homo sapiens
- Fersht, A R.
- Joerger, A C.
- Activator
- Anti-oncogene
- Apoptosis
- Cell cycle
- Disease mutation
- Dna-binding
- Dna-binding protein
- Glycoprotein
- Host-virus interaction
- Li- fraumeni syndrome
- Li-fraumeni syndrome
- Metal-binding
- Nuclear protein
- P53 dna-binding domain
- Phosphorylation
- Second-site suppressor mutation
- Superstable mutant
- Transcription
- Transcription regulation
- Transferase
- Tumor suppressor