2f9v: Difference between revisions

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[[Image:2f9v.png|left|200px]]
[[Image:2f9v.png|left|200px]]


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{{STRUCTURE_2f9v|  PDB=2f9v  |  SCENE=  }}  
{{STRUCTURE_2f9v|  PDB=2f9v  |  SCENE=  }}  


===HCV NS3 protease domain with NS4a peptide and a ketoamide inhibitor with P1 and P2 cyclopropylalannines===
===HCV NS3 protease domain with NS4a peptide and a ketoamide inhibitor with P1 and P2 cyclopropylalannines===


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{{ABSTRACT_PUBMED_16387495}}
{{ABSTRACT_PUBMED_16387495}}


==About this Structure==
==About this Structure==
[[2f9v]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F9V OCA].  
[[2f9v]] is a 4 chain structure of [[Helicase]] with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F9V OCA].  
 
==See Also==
*[[Helicase|Helicase]]


==Reference==
==Reference==
<ref group="xtra">PMID:16387495</ref><ref group="xtra">PMID:8861917</ref><ref group="xtra">PMID:16112862</ref><ref group="xtra">PMID:16078825</ref><ref group="xtra">PMID:16211639</ref><ref group="xtra">PMID:15501035</ref><references group="xtra"/>
<ref group="xtra">PMID:016387495</ref><ref group="xtra">PMID:008861917</ref><ref group="xtra">PMID:016112862</ref><ref group="xtra">PMID:016078825</ref><ref group="xtra">PMID:016211639</ref><ref group="xtra">PMID:015501035</ref><references group="xtra"/>
[[Category: Hepatitis c virus]]
[[Category: Hepatitis c virus]]
[[Category: Agrawal, S.]]
[[Category: Agrawal, S.]]

Revision as of 23:51, 26 July 2012

File:2f9v.png

Template:STRUCTURE 2f9v

HCV NS3 protease domain with NS4a peptide and a ketoamide inhibitor with P1 and P2 cyclopropylalanninesHCV NS3 protease domain with NS4a peptide and a ketoamide inhibitor with P1 and P2 cyclopropylalannines

Template:ABSTRACT PUBMED 16387495

About this StructureAbout this Structure

2f9v is a 4 chain structure of Helicase with sequence from Hepatitis c virus. Full crystallographic information is available from OCA.

See AlsoSee Also

ReferenceReference

[xtra 1][xtra 2][xtra 3][xtra 4][xtra 5][xtra 6]

  1. ↑ Bogen SL, Ruan S, Liu R, Agrawal S, Pichardo J, Prongay A, Baroudy B, Saksena AK, Girijavallabhan V, Njoroge FG. Depeptidization efforts on P3-P2' alpha-ketoamide inhibitors of HCV NS3-4A serine protease: effect on HCV replicon activity. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1621-7. Epub 2006 Jan 4. PMID:16387495 doi:10.1016/j.bmcl.2005.12.013
  2. ↑ Kim JL, Morgenstern KA, Lin C, Fox T, Dwyer MD, Landro JA, Chambers SP, Markland W, Lepre CA, O'Malley ET, Harbeson SL, Rice CM, Murcko MA, Caron PR, Thomson JA. Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide. Cell. 1996 Oct 18;87(2):343-55. PMID:8861917
  3. ↑ Bogen S, Saksena AK, Arasappan A, Gu H, Njoroge FG, Girijavallabhan V, Pichardo J, Butkiewicz N, Prongay A, Madison V. Hepatitis C virus NS3-4A serine protease inhibitors: use of a P2-P1 cyclopropyl alanine combination for improved potency. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4515-9. PMID:16112862 doi:10.1016/j.bmcl.2005.07.009
  4. ↑ Venkatraman S, Njoroge FG, Girijavallabhan VM, Madison VS, Yao NH, Prongay AJ, Butkiewicz N, Pichardo J. Design and synthesis of depeptidized macrocyclic inhibitors of hepatitis C NS3-4A protease using structure-based drug design. J Med Chem. 2005 Aug 11;48(16):5088-91. PMID:16078825 doi:10.1021/jm0489556
  5. ↑ Chen KX, Njoroge FG, Vibulbhan B, Prongay A, Pichardo J, Madison V, Buevich A, Chan TM. Proline-based macrocyclic inhibitors of the hepatitis C virus: stereoselective synthesis and biological activity. Angew Chem Int Ed Engl. 2005 Nov 4;44(43):7024-8. PMID:16211639 doi:10.1002/anie.200501553
  6. ↑ Arasappan A, Njoroge FG, Parekh TN, Yang X, Pichardo J, Butkiewicz N, Prongay A, Yao N, Girijavallabhan V. Novel 2-oxoimidazolidine-4-carboxylic acid derivatives as hepatitis C virus NS3-4A serine protease inhibitors: synthesis, activity, and X-ray crystal structure of an enzyme inhibitor complex. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5751-5. PMID:15501035 doi:10.1016/j.bmcl.2004.09.058

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