1f45: Difference between revisions
New page: left|200px<br /> <applet load="1f45" size="450" color="white" frame="true" align="right" spinBox="true" caption="1f45, resolution 2.8Å" /> '''HUMAN INTERLEUKIN-12... |
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[[Image:1f45.gif|left|200px]]<br /> | [[Image:1f45.gif|left|200px]]<br /><applet load="1f45" size="350" color="white" frame="true" align="right" spinBox="true" | ||
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caption="1f45, resolution 2.8Å" /> | caption="1f45, resolution 2.8Å" /> | ||
'''HUMAN INTERLEUKIN-12'''<br /> | '''HUMAN INTERLEUKIN-12'''<br /> | ||
==Overview== | ==Overview== | ||
Human interleukin-12 (IL-12, p70) is an early pro-inflammatory cytokine, comprising two disulfide-linked subunits, p35 and p40. We solved the | Human interleukin-12 (IL-12, p70) is an early pro-inflammatory cytokine, comprising two disulfide-linked subunits, p35 and p40. We solved the crystal structures of monomeric human p40 at 2.5 A and the human p70 complex at 2.8 A resolution, which reveals that IL-12 is similar to class 1 cytokine-receptor complexes. They also include the first description of an N-terminal immunoglobulin-like domain, found on the p40 subunit. Several charged residues from p35 and p40 intercalate to form a unique interlocking topography, shown by mutagenesis to be critical for p70 formation. A central arginine residue from p35 projects into a deep pocket on p40, which may be an ideal target for a small molecule antagonist of IL-12 formation. | ||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
1F45 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | 1F45 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F45 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Johnston, S | [[Category: Johnston, S C.]] | ||
[[Category: Somers, W | [[Category: Somers, W S.]] | ||
[[Category: Tang, J.]] | [[Category: Tang, J.]] | ||
[[Category: Tobin, J | [[Category: Tobin, J F.]] | ||
[[Category: Yoon, C.]] | [[Category: Yoon, C.]] | ||
[[Category: cytokine]] | [[Category: cytokine]] | ||
[[Category: interleukin]] | [[Category: interleukin]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:34:36 2008'' | ||
Revision as of 13:34, 21 February 2008
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HUMAN INTERLEUKIN-12
OverviewOverview
Human interleukin-12 (IL-12, p70) is an early pro-inflammatory cytokine, comprising two disulfide-linked subunits, p35 and p40. We solved the crystal structures of monomeric human p40 at 2.5 A and the human p70 complex at 2.8 A resolution, which reveals that IL-12 is similar to class 1 cytokine-receptor complexes. They also include the first description of an N-terminal immunoglobulin-like domain, found on the p40 subunit. Several charged residues from p35 and p40 intercalate to form a unique interlocking topography, shown by mutagenesis to be critical for p70 formation. A central arginine residue from p35 projects into a deep pocket on p40, which may be an ideal target for a small molecule antagonist of IL-12 formation.
DiseaseDisease
Known diseases associated with this structure: Asthma, susceptibility to OMIM:[161561], BCG and salmonella infection, disseminated OMIM:[161561], Psoriasis, susceptibility to OMIM:[161561]
About this StructureAbout this Structure
1F45 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12., Yoon C, Johnston SC, Tang J, Stahl M, Tobin JF, Somers WS, EMBO J. 2000 Jul 17;19(14):3530-41. PMID:10899108
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