Sandbox 122: Difference between revisions

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Wayne Decatur, Student, Allison Granberry, Marisa L. VanBrakle

Revision as of 19:23, 26 July 2012 view source Allison Granberry (talk \| contribs) 742 edits No edit summary ← Older edit		Revision as of 19:25, 26 July 2012 view source Allison Granberry (talk \| contribs) 742 edits No edit summary Newer edit →
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	Kapβ2 is a superhelix comprised of 20 HEAT repeats (the name HEAT derives from Huntington, Elongation factor 3 A subunit of protein phosphatase 2A and Tor1 kinase), each of which consists of two <scene name='Sandbox_122/Kapb2_blue_hr2_red/1'>anti-parallel helices.</scene> The electrostatic potential of the internal surface of Kapβ2 superhelix at the C-terminal arch is negative.		Kapβ2 is a superhelix comprised of 20 HEAT repeats (the name HEAT derives from Huntington, Elongation factor 3 A subunit of protein phosphatase 2A and Tor1 kinase), each of which consists of two <scene name='Sandbox_122/Kapb2_blue_hr2_red/1'>anti-parallel helices.</scene> The electrostatic potential of the internal surface of Kapβ2 superhelix at the C-terminal arch is negative.

	HEAT repeats <scene name='Sandbox_122/Kapb2_blue_hr9-13_pink/1'>9-13</scene> and <scene name='Sandbox_122/Kapb2_blue_hr14-18_pink/1'>14-18</scene> form the <scene name='Sandbox_122/Kapb2_blue_hr9-13_hr14-18_pink/1'>binding site</scene> of Kapβ2 cargos while repeats <scene name='Sandbox_122/Kapb2_blue_hr1-8_purple/1'>1-8</scene> constitute the ~~Ran GTPase~~ binding site.3 ~~Ran GTPase~~, a small 216-residue protein, is found more frequently in the nucleus and enables cargos to be released from Kapβ2.		HEAT repeats <scene name='Sandbox_122/Kapb2_blue_hr9-13_pink/1'>9-13</scene> and <scene name='Sandbox_122/Kapb2_blue_hr14-18_pink/1'>14-18</scene> form the <scene name='Sandbox_122/Kapb2_blue_hr9-13_hr14-18_pink/1'>binding site</scene> of Kapβ2 cargos while repeats <scene name='Sandbox_122/Kapb2_blue_hr1-8_purple/1'>1-8</scene> constitute the RanGTPase binding site.3 RanGTPase, a small 216-residue protein, is found more frequently in the nucleus and enables cargos to be released from Kapβ2.