1waq: Difference between revisions
New page: left|200px<br /> <applet load="1waq" size="450" color="white" frame="true" align="right" spinBox="true" caption="1waq, resolution 2.28Å" /> '''CRYSTAL STRUCTURE O... |
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==About this Structure== | ==About this Structure== | ||
1WAQ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with MPD as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1WAQ OCA]]. | 1WAQ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with MPD as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1WAQ OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: tgf-beta superfamily]] | [[Category: tgf-beta superfamily]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:56:33 2007'' | ||
Revision as of 14:51, 30 October 2007
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CRYSTAL STRUCTURE OF HUMAN GROWTH AND DIFFERENTIATION FACTOR 5 (GDF-5)
OverviewOverview
Growth and differentiation factor 5 (GDF-5), a member of the TGF-beta, superfamily, is involved in many developmental processes, like, chondrogenesis and joint formation. Mutations in GDF-5 lead to diseases, e.g. chondrodysplasias like Hunter-Thompson, Grebe and DuPan syndromes and, brachydactyly. Similar to other TGF-beta superfamily members, GDF-5, transmits signals through binding to two different types of membrane-bound, serine-/threonine-kinase receptors termed type I and type II. In contrast, to the large number of ligands, only seven type I and five type II, receptors have been identified to date, implicating a limited promiscuity, in ligand-receptor interaction. However, in contrast to other members of, the TGF-beta superfamily, GDF-5 shows a pronounced specificity in type I, ... [(full description)]
About this StructureAbout this Structure
1WAQ is a [Single protein] structure of sequence from [Homo sapiens] with MPD as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
A single residue of GDF-5 defines binding specificity to BMP receptor IB., Nickel J, Kotzsch A, Sebald W, Mueller TD, J Mol Biol. 2005 Jun 24;349(5):933-47. Epub 2005 Apr 22. PMID:15890363
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