1diw: Difference between revisions
New page: left|200px<br /><applet load="1diw" size="450" color="white" frame="true" align="right" spinBox="true" caption="1diw, resolution 2.0Å" /> '''THE HC FRAGMENT OF TE... |
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[[Image:1diw.gif|left|200px]]<br /><applet load="1diw" size=" | [[Image:1diw.gif|left|200px]]<br /><applet load="1diw" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1diw, resolution 2.0Å" /> | caption="1diw, resolution 2.0Å" /> | ||
'''THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH GALACTOSE'''<br /> | '''THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH GALACTOSE'''<br /> | ||
==Overview== | ==Overview== | ||
The entry of tetanus neurotoxin into neuronal cells proceeds through the | The entry of tetanus neurotoxin into neuronal cells proceeds through the initial binding of the toxin to gangliosides on the cell surface. The carboxyl-terminal fragment of the heavy chain of tetanus neurotoxin contains the ganglioside-binding site, which has not yet been fully characterized. The crystal structures of native H(C) and of H(C) soaked with carbohydrates reveal a number of binding sites and provide insight into the possible mode of ganglioside binding. | ||
==About this Structure== | ==About this Structure== | ||
1DIW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani] with GAL as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Tentoxilysin Tentoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.68 3.4.24.68] Full crystallographic information is available from [http:// | 1DIW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani] with <scene name='pdbligand=GAL:'>GAL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Tentoxilysin Tentoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.68 3.4.24.68] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DIW OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Tentoxilysin]] | [[Category: Tentoxilysin]] | ||
[[Category: Black, I.]] | [[Category: Black, I.]] | ||
[[Category: Charles, I | [[Category: Charles, I G.]] | ||
[[Category: Emsley, P.]] | [[Category: Emsley, P.]] | ||
[[Category: Fairweather, N | [[Category: Fairweather, N F.]] | ||
[[Category: Fotinou, C.]] | [[Category: Fotinou, C.]] | ||
[[Category: Hewitt, E.]] | [[Category: Hewitt, E.]] | ||
[[Category: Isaacs, N | [[Category: Isaacs, N W.]] | ||
[[Category: Watts, C.]] | [[Category: Watts, C.]] | ||
[[Category: GAL]] | [[Category: GAL]] | ||
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[[Category: jelly-roll]] | [[Category: jelly-roll]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:17:02 2008'' | ||
Revision as of 13:17, 21 February 2008
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THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH GALACTOSE
OverviewOverview
The entry of tetanus neurotoxin into neuronal cells proceeds through the initial binding of the toxin to gangliosides on the cell surface. The carboxyl-terminal fragment of the heavy chain of tetanus neurotoxin contains the ganglioside-binding site, which has not yet been fully characterized. The crystal structures of native H(C) and of H(C) soaked with carbohydrates reveal a number of binding sites and provide insight into the possible mode of ganglioside binding.
About this StructureAbout this Structure
1DIW is a Single protein structure of sequence from Clostridium tetani with as ligand. Active as Tentoxilysin, with EC number 3.4.24.68 Full crystallographic information is available from OCA.
ReferenceReference
The structures of the H(C) fragment of tetanus toxin with carbohydrate subunit complexes provide insight into ganglioside binding., Emsley P, Fotinou C, Black I, Fairweather NF, Charles IG, Watts C, Hewitt E, Isaacs NW, J Biol Chem. 2000 Mar 24;275(12):8889-94. PMID:10722735
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