1dd8: Difference between revisions

Revision as of 13:15, 21 February 2008

CRYSTAL STRUCTURE OF BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE I FROM ESCHERICHIA COLI

OverviewOverview

The crystal structure of the fatty acid elongating enzyme beta-ketoacyl [acyl carrier protein] synthase I (KAS I) from Escherichia coli has been determined to 2.3 A resolution by molecular replacement using the recently solved crystal structure of KAS II as a search model. The crystal contains two independent dimers in the asymmetric unit. KAS I assumes the thiolase alpha(beta)alpha(beta)alpha fold. Electrostatic potential distribution reveals an acyl carrier protein docking site and a presumed substrate binding pocket was detected extending the active site. Both subunits contribute to each substrate binding site in the dimer.

About this StructureAbout this Structure

1DD8 is a Single protein structure of sequence from Escherichia coli. Active as Beta-ketoacyl-acyl-carrier-protein synthase I, with EC number 2.3.1.41 Full crystallographic information is available from OCA.

ReferenceReference

The X-ray crystal structure of beta-ketoacyl [acyl carrier protein] synthase I., Olsen JG, Kadziola A, von Wettstein-Knowles P, Siggaard-Andersen M, Lindquist Y, Larsen S, FEBS Lett. 1999 Oct 22;460(1):46-52. PMID:10571059

Page seeded by OCA on Thu Feb 21 12:15:26 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:1dd8.gif|left|200px]]<br /><applet load="1dd8" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1dd8.gif|left|200px]]<br /><applet load="1dd8" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1dd8, resolution 2.3&Aring;" />
 '''CRYSTAL STRUCTURE OF BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE I FROM ESCHERICHIA COLI'''<br />
 ==Overview==
-The crystal structure of the fatty acid elongating enzyme beta-ketoacyl, [acyl carrier protein] synthase I (KAS I) from Escherichia coli has been, determined to 2.3 A resolution by molecular replacement using the recently, solved crystal structure of KAS II as a search model. The crystal contains, two independent dimers in the asymmetric unit. KAS I assumes the thiolase, alpha(beta)alpha(beta)alpha fold. Electrostatic potential distribution, reveals an acyl carrier protein docking site and a presumed substrate, binding pocket was detected extending the active site. Both subunits, contribute to each substrate binding site in the dimer.
+The crystal structure of the fatty acid elongating enzyme beta-ketoacyl [acyl carrier protein] synthase I (KAS I) from Escherichia coli has been determined to 2.3 A resolution by molecular replacement using the recently solved crystal structure of KAS II as a search model. The crystal contains two independent dimers in the asymmetric unit. KAS I assumes the thiolase alpha(beta)alpha(beta)alpha fold. Electrostatic potential distribution reveals an acyl carrier protein docking site and a presumed substrate binding pocket was detected extending the active site. Both subunits contribute to each substrate binding site in the dimer.
 ==About this Structure==
-DD8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Active as [http://en.wikipedia.org/wiki/Beta-ketoacyl-acyl-carrier-protein_synthase_I Beta-ketoacyl-acyl-carrier-protein synthase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.41 2.3.1.41] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DD8 OCA].
+DD8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Active as [http://en.wikipedia.org/wiki/Beta-ketoacyl-acyl-carrier-protein_synthase_I Beta-ketoacyl-acyl-carrier-protein synthase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.41 2.3.1.41] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DD8 OCA].
 ==Reference==
@@ Line 17: / Line 17: @@
 [[Category: Larsen, S.]]
 [[Category: Lindquist, Y.]]
-[[Category: Olsen, J.G.]]
+[[Category: Olsen, J G.]]
 [[Category: Siggaard-Andersen, M.]]
-[[Category: Wettstein-Knowles, P.von.]]
+[[Category: Wettstein-Knowles, P von.]]
 [[Category: thiolase fold]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 13:11:22 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:15:26 2008''