1d01: Difference between revisions

Revision as of 13:11, 21 February 2008

STRUCTURE OF TNF RECEPTOR ASSOCIATED FACTOR 2 IN COMPLEX WITH A HUMAN CD30 PEPTIDE

OverviewOverview

Many members of the tumor necrosis factor receptor (TNFR) superfamily initiate intracellular signaling by recruiting TNFR-associated factors (TRAFs) through their cytoplasmic tails. TRAFs apparently recognize highly diverse receptor sequences. Crystal structures of the TRAF domain of human TRAF2 in complex with peptides from the TNFR family members CD40, CD30, Ox40, 4-1BB, and the EBV oncoprotein LMP1 revealed a conserved binding mode. A major TRAF2-binding consensus sequence, (P/S/A/T)x(Q/E)E, and a minor consensus motif, PxQxxD, can be defined from the structural analysis, which encompass all known TRAF2-binding sequences. The structural information provides a template for the further dissection of receptor binding specificity of TRAF2 and for the understanding of the complexity of TRAF-mediated signal transduction.

About this StructureAbout this Structure

1D01 is a Protein complex structure of sequences from Homo sapiens with as ligand. Full crystallographic information is available from OCA.

ReferenceReference

The structural basis for the recognition of diverse receptor sequences by TRAF2., Ye H, Park YC, Kreishman M, Kieff E, Wu H, Mol Cell. 1999 Sep;4(3):321-30. PMID:10518213

Page seeded by OCA on Thu Feb 21 12:11:28 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1d01.gif|left|200px]]<br />
+[[Image:1d01.gif|left|200px]]<br /><applet load="1d01" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1d01" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1d01, resolution 2.0&Aring;" />
 '''STRUCTURE OF TNF RECEPTOR ASSOCIATED FACTOR 2 IN COMPLEX WITH A HUMAN CD30 PEPTIDE'''<br />
 ==Overview==
-Many members of the tumor necrosis factor receptor (TNFR) superfamily, initiate intracellular signaling by recruiting TNFR-associated factors, (TRAFs) through their cytoplasmic tails. TRAFs apparently recognize highly, diverse receptor sequences. Crystal structures of the TRAF domain of human, TRAF2 in complex with peptides from the TNFR family members CD40, CD30, Ox40, 4-1BB, and the EBV oncoprotein LMP1 revealed a conserved binding, mode. A major TRAF2-binding consensus sequence, (P/S/A/T)x(Q/E)E, and a, minor consensus motif, PxQxxD, can be defined from the structural, analysis, which encompass all known TRAF2-binding sequences. The, structural information provides a template for the further dissection of, receptor binding specificity of TRAF2 and for the understanding of the, complexity of TRAF-mediated signal transduction.
+Many members of the tumor necrosis factor receptor (TNFR) superfamily initiate intracellular signaling by recruiting TNFR-associated factors (TRAFs) through their cytoplasmic tails. TRAFs apparently recognize highly diverse receptor sequences. Crystal structures of the TRAF domain of human TRAF2 in complex with peptides from the TNFR family members CD40, CD30, Ox40, 4-1BB, and the EBV oncoprotein LMP1 revealed a conserved binding mode. A major TRAF2-binding consensus sequence, (P/S/A/T)x(Q/E)E, and a minor consensus motif, PxQxxD, can be defined from the structural analysis, which encompass all known TRAF2-binding sequences. The structural information provides a template for the further dissection of receptor binding specificity of TRAF2 and for the understanding of the complexity of TRAF-mediated signal transduction.
 ==About this Structure==
-D01 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ACE as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1D01 OCA].
+D01 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ACE:'>ACE</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D01 OCA].
 ==Reference==
@@ Line 16: / Line 15: @@
 [[Category: Kieff, E.]]
 [[Category: Kreishman, M.]]
-[[Category: Park, Y.C.]]
+[[Category: Park, Y C.]]
 [[Category: Wu, H.]]
 [[Category: Ye, H.]]
@@ Line 23: / Line 22: @@
 [[Category: protein-peptide complex]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:27:19 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:11:28 2008''