1cww: Difference between revisions
New page: left|200px<br /> <applet load="1cww" size="450" color="white" frame="true" align="right" spinBox="true" caption="1cww" /> '''SOLUTION STRUCTURE OF THE CASPASE RECRUITME... |
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[[Image:1cww.gif|left|200px]]<br /> | [[Image:1cww.gif|left|200px]]<br /><applet load="1cww" size="350" color="white" frame="true" align="right" spinBox="true" | ||
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'''SOLUTION STRUCTURE OF THE CASPASE RECRUITMENT DOMAIN (CARD) FROM APAF-1'''<br /> | '''SOLUTION STRUCTURE OF THE CASPASE RECRUITMENT DOMAIN (CARD) FROM APAF-1'''<br /> | ||
==Overview== | ==Overview== | ||
Activation of procaspase-9, a key component of the apoptosis mechanism, requires the interaction of its caspase recruitment domain (CARD) with the | Activation of procaspase-9, a key component of the apoptosis mechanism, requires the interaction of its caspase recruitment domain (CARD) with the CARD in the adaptor protein Apaf-1. Using nuclear magnetic resonance spectroscopy and mutagenesis we have determined the structure of the CARD from Apaf-1 and the residues important for binding the CARD in procaspase-9. Apaf-1's CARD contains seven short alpha-helices with the core six helices arranged in an antiparallel manner. Residues in helix 2 have a central role in mediating interaction with procaspase-9 CARD. This interaction surface is distinct from that proposed based on the structure of the CARD from RAIDD, but is coincident with that of the structurally similar FADD death effector domain and the Apaf-1 CARD interface identified by crystallographic studies. | ||
==About this Structure== | ==About this Structure== | ||
1CWW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | 1CWW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CWW OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Day, C | [[Category: Day, C L.]] | ||
[[Category: Dupont, C.]] | [[Category: Dupont, C.]] | ||
[[Category: Hinds, M | [[Category: Hinds, M G.]] | ||
[[Category: Lackmann, M.]] | [[Category: Lackmann, M.]] | ||
[[Category: Vaux, D | [[Category: Vaux, D L.]] | ||
[[Category: helical bundle]] | [[Category: helical bundle]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:10:34 2008'' | ||
