1tb6: Difference between revisions

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{{Seed}}
[[Image:1tb6.png|left|200px]]
[[Image:1tb6.png|left|200px]]


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{{STRUCTURE_1tb6|  PDB=1tb6  |  SCENE=  }}  
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===2.5A Crystal Structure of the Antithrombin-Thrombin-Heparin Ternary Complex===
===2.5A Crystal Structure of the Antithrombin-Thrombin-Heparin Ternary Complex===


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{{ABSTRACT_PUBMED_15311269}}
{{ABSTRACT_PUBMED_15311269}}


==Disease==
==About this Structure==
Known disease associated with this structure: Dysprothrombinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176930 176930]], Hyperprothrombinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176930 176930]], Hypoprothrombinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176930 176930]]
[[1tb6]] is a 3 chain structure of [[Antithrombin]] and [[Thrombin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TB6 OCA].


==About this Structure==
==See Also==
1TB6 is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TB6 OCA].
*[[Antithrombin|Antithrombin]]
*[[Thrombin|Thrombin]]


==Reference==
==Reference==
<ref group="xtra">PMID:15311269</ref><references group="xtra"/>
<ref group="xtra">PMID:015311269</ref><ref group="xtra">PMID:016673263</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Thrombin]]
[[Category: Thrombin]]
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[[Category: Li, W.]]
[[Category: Li, W.]]
[[Category: Heparin]]
[[Category: Heparin]]
 
[[Category: Hydrolase-blood clotting complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 23:49:44 2009''

Revision as of 05:25, 26 July 2012

File:1tb6.png

Template:STRUCTURE 1tb6

2.5A Crystal Structure of the Antithrombin-Thrombin-Heparin Ternary Complex2.5A Crystal Structure of the Antithrombin-Thrombin-Heparin Ternary Complex

Template:ABSTRACT PUBMED 15311269

About this StructureAbout this Structure

1tb6 is a 3 chain structure of Antithrombin and Thrombin with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See AlsoSee Also

ReferenceReference

[xtra 1][xtra 2]

  1. ↑ Li W, Johnson DJ, Esmon CT, Huntington JA. Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin. Nat Struct Mol Biol. 2004 Sep;11(9):857-62. Epub 2004 Aug 15. PMID:15311269 doi:10.1038/nsmb811
  2. ↑ Bode W. The structure of thrombin: a janus-headed proteinase. Semin Thromb Hemost. 2006 Apr;32 Suppl 1:16-31. PMID:16673263 doi:10.1055/s-2006-939551

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