3hr1: Difference between revisions
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[[Image:3hr1.png|left|200px]] | [[Image:3hr1.png|left|200px]] | ||
{{STRUCTURE_3hr1| PDB=3hr1 | SCENE= }} | {{STRUCTURE_3hr1| PDB=3hr1 | SCENE= }} | ||
===Discovery of novel inhibitors of PDE10A=== | ===Discovery of novel inhibitors of PDE10A=== | ||
{{ABSTRACT_PUBMED_19630403}} | {{ABSTRACT_PUBMED_19630403}} | ||
==About this Structure== | ==About this Structure== | ||
[[3hr1]] is a 1 chain structure of [[Phosphodiesterase]] with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HR1 OCA]. | |||
==See Also== | |||
*[[Phosphodiesterase|Phosphodiesterase]] | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:019630403</ref><references group="xtra"/> | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Marr, E S.]] | [[Category: Marr, E S.]] | ||
[[Category: Pandit, J.]] | [[Category: Pandit, J.]] | ||
[[Category: Allosteric enzyme]] | [[Category: Allosteric enzyme]] | ||
[[Category: Camp]] | [[Category: Camp]] | ||
[[Category: Camp-binding]] | [[Category: Camp-binding]] | ||
[[Category: Cgmp]] | [[Category: Cgmp]] | ||
[[Category: Cgmp-binding]] | [[Category: Cgmp-binding]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Hydrolase | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
[[Category: Magnesium]] | [[Category: Magnesium]] | ||
[[Category: Metal-binding]] | [[Category: Metal-binding]] | ||
| Line 42: | Line 31: | ||
[[Category: Pde10 inhibitor]] | [[Category: Pde10 inhibitor]] | ||
[[Category: Phosphodiesterase 10a]] | [[Category: Phosphodiesterase 10a]] | ||
Revision as of 05:09, 26 July 2012
Discovery of novel inhibitors of PDE10ADiscovery of novel inhibitors of PDE10A
Template:ABSTRACT PUBMED 19630403
About this StructureAbout this Structure
3hr1 is a 1 chain structure of Phosphodiesterase with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
See AlsoSee Also
ReferenceReference
- ↑ Verhoest PR, Chapin DS, Corman M, Fonseca K, Harms JF, Hou X, Marr ES, Menniti FS, Nelson F, O'Connor R, Pandit J, Proulx-Lafrance C, Schmidt AW, Schmidt CJ, Suiciak JA, Liras S. Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia (dagger) dagger Coordinates of the PDE10A crystal structures have been deposited in the Protein Data Bank for compound 1 (3HQW), 2 (3HQY), 3 (3HQW) and 9 (3HR1). J Med Chem. 2009 Jul 24. PMID:19630403 doi:10.1021/jm900521k