2v22: Difference between revisions

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[[Image:2v22.png|left|200px]]
[[Image:2v22.png|left|200px]]


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{{STRUCTURE_2v22|  PDB=2v22  |  SCENE=  }}  
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===REPLACE: A STRATEGY FOR ITERATIVE DESIGN OF CYCLIN BINDING GROOVE INHIBITORS===
===REPLACE: A STRATEGY FOR ITERATIVE DESIGN OF CYCLIN BINDING GROOVE INHIBITORS===


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{{ABSTRACT_PUBMED_17051658}}
{{ABSTRACT_PUBMED_17051658}}


==About this Structure==
==About this Structure==
[[2v22]] is a 4 chain structure of [[Cell Division Protein Kinase 2]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V22 OCA].  
[[2v22]] is a 4 chain structure of [[Cell Division Protein Kinase 2]] and [[Cyclin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V22 OCA].  


==See Also==
==See Also==
*[[Cell Division Protein Kinase 2]]
*[[Cell Division Protein Kinase 2|Cell Division Protein Kinase 2]]
*[[Cyclin|Cyclin]]


==Reference==
==Reference==
<ref group="xtra">PMID:17051658</ref><ref group="xtra">PMID:16492568</ref><references group="xtra"/>
<ref group="xtra">PMID:017051658</ref><ref group="xtra">PMID:016492568</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Nucleotide-binding]]
[[Category: Nucleotide-binding]]
[[Category: Phosphorylation]]
[[Category: Phosphorylation]]
[[Category: Polymorphism]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Transferase]]
[[Category: Transferase]]

Revision as of 04:03, 26 July 2012

File:2v22.png

Template:STRUCTURE 2v22

REPLACE: A STRATEGY FOR ITERATIVE DESIGN OF CYCLIN BINDING GROOVE INHIBITORSREPLACE: A STRATEGY FOR ITERATIVE DESIGN OF CYCLIN BINDING GROOVE INHIBITORS

Template:ABSTRACT PUBMED 17051658

About this StructureAbout this Structure

2v22 is a 4 chain structure of Cell Division Protein Kinase 2 and Cyclin with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See AlsoSee Also

ReferenceReference

[xtra 1][xtra 2]

  1. ↑ Andrews MJ, Kontopidis G, McInnes C, Plater A, Innes L, Cowan A, Jewsbury P, Fischer PM. REPLACE: a strategy for iterative design of cyclin-binding groove inhibitors. Chembiochem. 2006 Dec;7(12):1909-15. PMID:17051658 doi:10.1002/cbic.200600189
  2. ↑ Kontopidis G, McInnes C, Pandalaneni SR, McNae I, Gibson D, Mezna M, Thomas M, Wood G, Wang S, Walkinshaw MD, Fischer PM. Differential binding of inhibitors to active and inactive CDK2 provides insights for drug design. Chem Biol. 2006 Feb;13(2):201-11. PMID:16492568 doi:http://dx.doi.org/10.1016/j.chembiol.2005.11.011

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