1cdd: Difference between revisions

Revision as of 13:04, 21 February 2008

STRUCTURES OF APO AND COMPLEXED ESCHERICHIA COLI GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE

OverviewOverview

The three-dimensional structure of phosphoribosylglycinamide formyltransferase (10-formyltetrahydrofolate:5'-phosphoribosylglycinamide formyltransferase, EC 2.1.2.2) has been solved both as an apoenzyme at 2.8-A resolution and as a ternary complex with the substrate glycinamide ribonucleotide and a folate inhibitor at 2.5-A resolution. The structure is a modified doubly wound alpha/beta sheet with flexibility in the active site, including a disordered loop in the apo structure, which is ordered in the ternary complex structure. This enzyme is a target for anti-cancer therapy and now for structure-based drug design.

About this StructureAbout this Structure

1CDD is a Single protein structure of sequence from Escherichia coli with as ligand. Active as Phosphoribosylglycinamide formyltransferase, with EC number 2.1.2.2 Full crystallographic information is available from OCA.

ReferenceReference

Structures of apo and complexed Escherichia coli glycinamide ribonucleotide transformylase., Almassy RJ, Janson CA, Kan CC, Hostomska Z, Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):6114-8. PMID:1631098

Page seeded by OCA on Thu Feb 21 12:04:51 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:1cdd.gif|left|200px]]<br /><applet load="1cdd" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1cdd.gif|left|200px]]<br /><applet load="1cdd" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1cdd, resolution 2.8&Aring;" />
 '''STRUCTURES OF APO AND COMPLEXED ESCHERICHIA COLI GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE'''<br />
 ==Overview==
-The three-dimensional structure of phosphoribosylglycinamide, formyltransferase (10-formyltetrahydrofolate:5'-phosphoribosylglycinamide, formyltransferase, EC 2.1.2.2) has been solved both as an apoenzyme at, 2.8-A resolution and as a ternary complex with the substrate glycinamide, ribonucleotide and a folate inhibitor at 2.5-A resolution. The structure, is a modified doubly wound alpha/beta sheet with flexibility in the active, site, including a disordered loop in the apo structure, which is ordered, in the ternary complex structure. This enzyme is a target for anti-cancer, therapy and now for structure-based drug design.
+The three-dimensional structure of phosphoribosylglycinamide formyltransferase (10-formyltetrahydrofolate:5'-phosphoribosylglycinamide formyltransferase, EC 2.1.2.2) has been solved both as an apoenzyme at 2.8-A resolution and as a ternary complex with the substrate glycinamide ribonucleotide and a folate inhibitor at 2.5-A resolution. The structure is a modified doubly wound alpha/beta sheet with flexibility in the active site, including a disordered loop in the apo structure, which is ordered in the ternary complex structure. This enzyme is a target for anti-cancer therapy and now for structure-based drug design.
 ==About this Structure==
-CDD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with PO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Phosphoribosylglycinamide_formyltransferase Phosphoribosylglycinamide formyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.2 2.1.2.2] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1CDD OCA].
+CDD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=PO4:'>PO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Phosphoribosylglycinamide_formyltransferase Phosphoribosylglycinamide formyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.2 2.1.2.2] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CDD OCA].
 ==Reference==
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 [[Category: Phosphoribosylglycinamide formyltransferase]]
 [[Category: Single protein]]
-[[Category: Almassy, R.J.]]
+[[Category: Almassy, R J.]]
 [[Category: Hostomska, Z.]]
-[[Category: Janson, C.A.]]
+[[Category: Janson, C A.]]
-[[Category: Kan, C.C.]]
+[[Category: Kan, C C.]]
 [[Category: PO4]]
 [[Category: transferase(formyl)]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 12:21:54 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:04:51 2008''