2cj0: Difference between revisions
New page: left|200px<br /> <applet load="2cj0" size="450" color="white" frame="true" align="right" spinBox="true" caption="2cj0, resolution 1.75Å" /> '''CHLOROPEROXIDASE CO... |
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==About this Structure== | ==About this Structure== | ||
2CJ0 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Leptoxyphium_fumago Leptoxyphium fumago]] with NAG, MAN, MN, NO3, HEM and EDO as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.10 1.11.1.10]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CJ0 OCA]]. | 2CJ0 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Leptoxyphium_fumago Leptoxyphium fumago]] with NAG, MAN, MN, NO3, HEM and EDO as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Chloride_peroxidase Chloride peroxidase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.10 1.11.1.10]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CJ0 OCA]]. | ||
==Reference== | ==Reference== | ||
Crystal structures of chloroperoxidase with its bound substrates and complexed with formate, acetate, and nitrate., Kuhnel K, Blankenfeldt W, Terner J, Schlichting I, J Biol Chem. 2006 Aug 18;281(33):23990-8. Epub 2006 Jun 20. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16790441 16790441] | Crystal structures of chloroperoxidase with its bound substrates and complexed with formate, acetate, and nitrate., Kuhnel K, Blankenfeldt W, Terner J, Schlichting I, J Biol Chem. 2006 Aug 18;281(33):23990-8. Epub 2006 Jun 20. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16790441 16790441] | ||
[[Category: Chloride peroxidase]] | |||
[[Category: Leptoxyphium fumago]] | [[Category: Leptoxyphium fumago]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: pyrrolidone carboxylic acid]] | [[Category: pyrrolidone carboxylic acid]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:44:35 2007'' | ||
Revision as of 14:39, 30 October 2007
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CHLOROPEROXIDASE COMPLEXED WITH NITRATE
OverviewOverview
Chloroperoxidase (CPO) is a heme-thiolate enzyme that catalyzes hydrogen, peroxide-dependent halogenation reactions. Structural data on substrate, binding have not been available so far. CPO was therefore crystallized in, the presence of iodide or bromide. One halide binding site was identified, at the surface near a narrow channel that connects the surface with the, heme. Two other halide binding sites were identified within and at the, other end of this channel. Together, these sites suggest a pathway for, access of halide anions to the active site. The structure of CPO complexed, with its natural substrate cyclopentanedione was determined at a, resolution of 1.8 A. This is the first example of a CPO structure with a, bound organic substrate. In addition, structures of CPO bound with, ... [(full description)]
About this StructureAbout this Structure
2CJ0 is a [Single protein] structure of sequence from [Leptoxyphium fumago] with NAG, MAN, MN, NO3, HEM and EDO as [ligands]. Active as [Chloride peroxidase], with EC number [1.11.1.10]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
Crystal structures of chloroperoxidase with its bound substrates and complexed with formate, acetate, and nitrate., Kuhnel K, Blankenfeldt W, Terner J, Schlichting I, J Biol Chem. 2006 Aug 18;281(33):23990-8. Epub 2006 Jun 20. PMID:16790441
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